| ADR Ontology |
| ADR Term |
Dermatomyositis |
| ADR ID |
BADD_A01225 |
| ADR Hierarchy |
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| Description |
A subacute or chronic inflammatory disease of muscle and skin, marked by proximal muscle weakness and a characteristic skin rash. The illness occurs with approximately equal frequency in children and adults. The skin lesions usually take the form of a purplish rash (or less often an exfoliative dermatitis) involving the nose, cheeks, forehead, upper trunk, and arms. The disease is associated with a complement mediated intramuscular microangiopathy, leading to loss of capillaries, muscle ischemia, muscle-fiber necrosis, and perifascicular atrophy. The childhood form of this disease tends to evolve into a systemic vasculitis. Dermatomyositis may occur in association with malignant neoplasms. (From Adams et al., Principles of Neurology, 6th ed, pp1405-6) [MeSH] |
| MedDRA Code |
10012503 |
| MeSH ID |
D003882
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ADR Severity Grade (FAERS)
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ADR Severity Grade (CTCAE)
|
Not Available
|
| Synonym |
| Adult dermatomyositis | Childhood dermatomyositis | Dermatomyositis | Gottron's papules | Polymyositis-Dermatomyositis | Polymyositis Dermatomyositis | Dermatomyositis, Adult Type | Adult Type Dermatomyositis | Dermatomyositis, Childhood Type | Childhood Type Dermatomyositis | Juvenile Dermatomyositis | Dermatomyositis, Juvenile | Dermatopolymyositis | Juvenile Myositis | Myositis, Juvenile |
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| ADR Related Proteins |
| Protein Name |
UniProt AC |
TTD Target ID |
| HLA-DR4 protein | O77963 | Not Available | | MHC class I antigen | O19755 | Not Available | | MHC class I antigen HLA-B18 | O77967 | Not Available |
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| Drugs Leading to the ADR |
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