Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Cervical dysplasia
ADR ID BADD_A00862
ADR Hierarchy
21      Reproductive system and breast disorders
21.06      Cervix disorders (excl infections and inflammations)
21.06.01      Cervix disorders NEC
21.06.01.002      Cervical dysplasia
Description A malignancy arising in uterine cervical epithelium and confined thereto, representing a continuum of histological changes ranging from well-differentiated CIN 1 (formerly, mild dysplasia) to severe dysplasia/carcinoma in situ, CIN 3. The lesion arises at the squamocolumnar cell junction at the transformation zone of the endocervical canal, with a variable tendency to develop invasive epidermoid carcinoma, a tendency that is enhanced by concomitant human papillomaviral infection. (Segen, Dictionary of Modern Medicine, 1992) [MeSH]
MedDRA Code 10008263
MeSH ID D018290; D065309
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Cervical dyskaryosis | Cervical dysplasia | Cervical smear pos class III to V | Cervical smear positive class (3-5) | Dysplasia of cervix (uteri) | Koilocytotic pap smear | Cervical intraepithelial neoplasia I | Cervical intraepithelial neoplasia II | Cervical intraepithelial neoplasia III | Cervical intraepithelial neoplasia NOS | Cervical intraepithelial neoplasia | Atypical squamous cells of undetermined significance | Atypical squamous cells, cannot exclude HSIL | Low grade squamous intraepithelial lesion | High grade squamous intraepithelial lesion | ASC-US | ASC-H | LSIL | HSIL | Papanicolaou smear unspecifiable, class II W | Papanicolaou smear abnormal, class III | Papanicolaou smear abnormal, class III D | Cervical high grade squamous intraepithelial lesion | Cervical low grade squamous intraepithelial lesion | Koilocytotic atypia | Koilocytosis | Dysplasia cervical recurrent | AGUS | Atypical glandular cells of undetermined significance | Cervical Intraepithelial Neoplasia | Neoplasia, Cervical Intraepithelial | Cervical Intraepithelial Neoplasms | Cervical Intraepithelial Neoplasm | Intraepithelial Neoplasm, Cervical | Intraepithelial Neoplasms, Cervical | Neoplasm, Cervical Intraepithelial | Neoplasms, Cervical Intraepithelial | Intraepithelial Neoplasia, Cervical | Cervical Intraepithelial Neoplasia, Grade III
ADR Related Proteins
Protein Name UniProt AC TTD Target ID
Not AvailableNot AvailableNot Available
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00066Alendronic acid0.000404%
BADD_D00195Azathioprine0.003590%
BADD_D00499Clomipramine--
BADD_D00500Clomipramine hydrochloride--
BADD_D00574Dalfampridine0.002614%
BADD_D00680Dimethyl fumarate0.006418%
BADD_D00794Ergocalciferol0.000102%
BADD_D01020Glatiramer--
BADD_D01021Glatiramer acetate--
BADD_D01250Lasofoxifene--
BADD_D01281Levonorgestrel0.074000%
BADD_D01366Medroxyprogesterone acetate--
BADD_D01617Ondansetron0.000150%
BADD_D01834Prednisone0.000040%
BADD_D02105Tacrolimus0.001419%
BADD_D02165Teriflunomide0.002316%
BADD_D02213Tibolone--
BADD_D02325Valdecoxib--
BADD_D02464Fingolimod0.027213%
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