Adverse Drug Reaction Classification System

ADR Ontology
ADR Term IIIrd nerve paralysis
ADR ID BADD_A02239
ADR Hierarchy
06      Eye disorders
06.05      Ocular neuromuscular disorders
06.05.02      Ocular nerve and muscle disorders
06.05.02.011      IIIrd nerve paralysis
17      Nervous system disorders
17.04      Cranial nerve disorders (excl neoplasms)
17.04.02      Eye movement disorders
17.04.02.003      IIIrd nerve paralysis
Description Diseases of the oculomotor nerve or nucleus that result in weakness or paralysis of the superior rectus, inferior rectus, medial rectus, inferior oblique, or levator palpebrae muscles, or impaired parasympathetic innervation to the pupil. With a complete oculomotor palsy, the eyelid will be paralyzed, the eye will be in an abducted and inferior position, and the pupil will be markedly dilated. Commonly associated conditions include neoplasms, CRANIOCEREBRAL TRAUMA, ischemia (especially in association with DIABETES MELLITUS), and aneurysmal compression. (From Adams et al., Principles of Neurology, 6th ed, p270) [MeSH]
MedDRA Code 10021283
MeSH ID D015840; D009886
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Cranial third nerve paralysis | IIIrd nerve palsy | IIIrd nerve paralysis | Oculomotor nerve paralysis | Oculomotor paralysis | Paralysis oculomotor | Third nerve paralysis | Third or oculomotor nerve palsy, partial | Third or oculomotor nerve palsy, total | Oculomotor Nerve Diseases | Nerve Disease, Oculomotor | Nerve Diseases, Oculomotor | Oculomotor Nerve Disease | Oculomotor Nerve Paralysis | Nerve Paralyses, Oculomotor | Nerve Paralysis, Oculomotor | Oculomotor Nerve Paralyses | Paralyses, Oculomotor Nerve | Paralysis, Oculomotor Nerve | Third-Nerve Palsy | Palsies, Third-Nerve | Palsy, Third-Nerve | Third Nerve Palsy | Third-Nerve Palsies | Third-Nerve Paralysis | Paralyses, Third-Nerve | Paralysis, Third-Nerve | Third Nerve Paralysis | Third-Nerve Paralyses | Third Cranial Nerve Diseases | Cranial Nerve III Diseases | Oculomotor Nerve Disorders | Nerve Disorder, Oculomotor | Nerve Disorders, Oculomotor | Oculomotor Nerve Disorder | Oculomotor Neuropathy | Neuropathies, Oculomotor | Neuropathy, Oculomotor | Oculomotor Neuropathies | Oculomotor Nerve Palsy | Nerve Palsies, Oculomotor | Nerve Palsy, Oculomotor | Oculomotor Nerve Palsies | Palsies, Oculomotor Nerve | Palsy, Oculomotor Nerve | Partial Third-Nerve Palsy | Palsies, Partial Third-Nerve | Palsy, Partial Third-Nerve | Partial Third Nerve Palsy | Partial Third-Nerve Palsies | Third-Nerve Palsies, Partial | Third-Nerve Palsy, Partial | Total Third-Nerve Palsy | Palsies, Total Third-Nerve | Palsy, Total Third-Nerve | Third-Nerve Palsies, Total | Third-Nerve Palsy, Total | Total Third Nerve Palsy | Total Third-Nerve Palsies
ADR Related Proteins
Protein Name UniProt AC TTD Target ID
Not AvailableNot AvailableNot Available
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00061Alcohol--
BADD_D00195Azathioprine0.001436%
BADD_D00329Cabergoline0.033030%
BADD_D00371Carmustine0.000533%
BADD_D00415Cerivastatin--
BADD_D00499Clomipramine--
BADD_D00500Clomipramine hydrochloride--
BADD_D00564Dabigatran etexilate0.001055%
BADD_D00948Fluvastatin--
BADD_D01003Ganciclovir--
BADD_D01004Ganciclovir sodium--
BADD_D01038Goserelin--
BADD_D01119Ibrutinib0.000533%
BADD_D01167Interferon alfa-2b--
BADD_D01260Leuprolide acetate--
BADD_D01261Leuprolide monoacetate--
BADD_D01325Lovastatin--
BADD_D01366Medroxyprogesterone acetate--
BADD_D01513Nafarelin--
BADD_D01549Nelarabine--
BADD_D01824Pravastatin--
BADD_D01835Pregabalin0.000236%
BADD_D02018Sildenafil0.000831%
BADD_D02026Simvastatin--
BADD_D02105Tacrolimus0.002129%
BADD_D02270Tretinoin--
BADD_D02297Triptorelin--
BADD_D02464Fingolimod0.001158%
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