Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Alcohol
Drug ID BADD_D00061
Description A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant. It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as the primary ingredient in alcoholic beverages.
Indications and Usage For therapeutic neurolysis of nerves or ganglia for the relief of intractable chronic pain in such conditions as inoperable cancer and trigeminal neuralgia (tic douloureux), in patients for whom neurosurgical procedures are contraindicated.
Marketing Status Not Available
ATC Code D08AX08; V03AB16; V03AZ01
DrugBank ID DB00898
KEGG ID D00068
MeSH ID D000431
PubChem ID 702
TTD Drug ID D00AMQ
NDC Product Code 70483-019; 76891-101; 73088-203; 79363-706; 78020-333; 79332-005; 79203-000; 67385-024; 24208-061; 79937-003; 78082-011; 62651-067; 70000-0320; 56136-378; 51452-104; 72476-370; 76813-005; 78706-018; 62670-6088; 54748-403; 77770-003; 55533-523; 77678-002; 73932-0009; 73932-0012; 75444-104; 78082-008; 19392-130; 62670-6245; 76720-011; 81181-001; 76751-712; 74773-0031; 72866-008; 81448-001; 76618-001; 65585-373; 77269-300; 82320-003; 79052-023; 74514-3003; 79249-027; 73517-127; 79138-003; 14051-221; 69950-024; 73746-042; 37808-370; 77441-1004; 66715-0370; 73418-039; 56136-361; 62670-6105; 79091-006; 78082-020; 72197-004; 75363-0002; 76756-180; 74773-0025; 73931-003; 56136-367; 72197-035; 75427-002; 72667-014; 75690-001; 78789-033; 71095-010; 76751-713; 61354-038; 76882-0004; 80684-056; 75585-070; 73796-110; 76569-113; 47593-617; 77435-111; 62651-055; 79443-898; 73823-030; 78713-000; 42947-500; 71160-189; 77435-012; 76813-014; 73823-100; 11429-1004; 72487-006; 74201-338; 73823-201; 70589-114; 63940-614; 81101-200; 78713-001; 78706-004; 79288-012; 81451-113; 53943-370; 73746-040; 55533-524; 76720-010; 80899-001; 55715-004; 76598-005; 74177-026; 78974-0001; 78230-002; 51452-102; 64950-025; 74177-023; 80022-000; 75353-614; 70818-028; 73829-106; 54860-370; 78813-060; 74149-020; 76891-109; 54860-227; 59883-301; 78789-034; 80026-007; 73932-1000; 78174-017; 80627-001; 79138-001; 78789-055; 74177-985; 79249-026; 73818-201; 79996-900; 58503-147; 60637-088; 76751-711; 62670-6251; 78789-044; 81235-000; 77441-1015; 73797-100; 80026-014; 73708-619; 70956-005; 56136-347; 78702-000; 79103-000; 73898-002; 74443-030; 90015-005; 77984-007; 86818-003; 74934-044; 60637-143; 74279-0019; 79324-001; 75241-000; 59900-123; 70956-003; 77427-7444; 80684-030; 73823-001; 73931-010; 78815-203; 75532-002; 74274-022; 81139-000; 56136-397; 77427-6311; 74003-010; 56136-303; 55718-116; 74149-004; 76786-073; 73517-124; 76598-008; 80685-0429; 75601-0001; 72762-002; 54748-504; 54748-303; 73833-003; 74339-7570; 74274-009; 77984-006; 78768-001; 77669-001; 81730-111; 78789-023; 78280-302; 62651-027; 75632-200; 41190-439; 78804-777; 72697-0001; 62670-6119; 79103-002; 73818-200; 75585-030; 64942-1736; 79989-001; 80689-000; 77006-061; 76554-003; 79481-0849; 81054-000; 75421-001; 79071-1004; 82320-001; 56136-345; 74274-012; 73978-001; 73781-001; 59078-809; 75682-600; 60933-062; 61577-1112; 74819-0002; 78233-013; 61354-019; 77441-1012; 75363-0001; 61354-027; 56136-414; 78789-003; 79965-007; 72033-113; 79147-011; 65910-015; 80204-006; 81874-003; 78932-005; 74313-376; 21749-364; 56136-411; 77435-103; 79311-001; 79996-350; 63804-6001; 81562-005; 81562-001; 54699-016; 61577-1118; 78789-048; 79861-003; 71875-800; 80204-039; 73025-168; 61577-1113; 62670-6227; 69540-0037; 74730-002; 21749-812; 75262-005; 73453-143; 51531-1111; 60637-200; 79087-401; 62712-665; 75749-006; 61034-004; 73931-015; 69394-001; 73898-007; 78623-275; 56136-312; 78789-004; 77064-013; 41250-396; 78754-001; 80139-101; 29500-9361; 73697-110; 51414-911; 56136-096; 81571-001; 78918-101; 74339-9162; 79940-003; 73833-001; 78789-039; 60577-002; 66902-444; 79091-010; 81109-001; 78789-008; 50522-221; 49035-827; 21749-526; 73931-014; 74115-003; 79587-200; 78789-024; 71513-220; 77538-006; 54748-506; 75773-575; 50302-000; 90692-002; 73807-004; 73819-0003; 76782-003; 78662-700
Synonyms Ethanol | Grain Alcohol | Alcohol, Grain | Alcohol, Ethyl | Ethyl Alcohol | Absolute Alcohol | Alcohol, Absolute
Chemical Information
Molecular Formula C2H6O
CAS Registry Number 64-17-5
SMILES CCO
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Adrenogenital syndromeGrowth hormone receptorP16882Not Available12436059; 8722619; 8749812; 14726438
Adrenogenital syndromeReceptor protein-tyrosine kinaseQ6QHH2Not Available12436059; 8722619; 8749812; 14726438
Alcohol abuseSerotransferrinP02787T0261711003208; 11003206; 16185209
Alcohol poisoningProtein c-FosP01100T2802512130710; 12127099; 15229233; 12442202
Alcohol poisoningMitogen-activated protein kinase 1P28482T5897012130710; 12127099; 15229233; 12442202
Alcohol poisoningGamma-aminobutyric acid receptor subunit alpha-1P62813Not Available25713389
Alcohol poisoningOpioid growth factor receptorQ9NZT2T1374112130710; 12127099; 15229233; 12442202
Alcohol poisoningMitogen-activated protein kinase 1P28482T589709884156; 10371394; 7542850; 8758899
Alcohol poisoningSignal transducer and activator of transcription 3P40763T2913012130710; 12127099; 15229233; 12442202
Alcohol poisoningGamma-aminobutyric acid type A receptor subunit rho1Q5TZ16Not Available12130710; 12127099; 15229233; 12442202
Alcohol withdrawal syndromeSerotransferrinP02787T0261711003208; 11003206; 16185209
Alcohol withdrawal syndromeCannabinoid receptor 1Q71SP5Not Available11841893; 9394104; 14714115
Bone lesionSex hormone-binding globulinP04278Not Available2222569; 2988390; 1933604; 14555259; 10814601; 2045462; 14619387; 8333602; 15632479; 11398600; 7715435; 9310082; 14704297; 3754648; 14506413
Delayed pubertyReceptor protein-tyrosine kinaseQ6QHH2Not Available12436059; 8722619; 8749812; 14726438
Delayed pubertyGrowth hormone receptorP16882Not Available12436059; 8722619; 8749812; 14726438
DyskinesiaPro-thyrotropin-releasing hormoneP01150Not AvailableNot Available
Hepatic fibrosisCyclic AMP-responsive element-binding protein 1P15337Not Available25701503
Hepatic fibrosisAdenosine receptor A2aP30543Not Available25701503
Hepatic fibrosiscAMP-dependent protein kinase catalytic subunit alphaP27791Not Available25701503
HyperparathyroidismParathyroid hormone/parathyroid hormone-related peptide receptorQ03431T677102222569; 2988390; 1933604; 14555259; 10814601; 2045462; 14619387; 8333602; 15632479; 11398600; 7715435; 9310082; 14704297; 3754648; 14506413
HyperphosphatasaemiaCytochrome P450Q80XK1Not Available25804444
Liver injuryMitogen-activated protein kinase 1P28482T589709884156; 10371394; 7542850; 8758899
Liver injuryInsulin receptor substrate 1P35568T155109884156; 10371394; 7542850; 8758899
Liver injuryCytochrome P450Q80XK1Not Available25804444
Liver injuryGlyceraldehyde-3-phosphate dehydrogenaseP04406T393219884156; 10371394; 7542850; 8758899
Liver injuryMitogen-activated protein kinase 1P28482T5897012130710; 12127099; 15229233; 12442202
Liver injuryProliferating cell nuclear antigenQ00268Not Available9884156; 10371394; 7542850; 8758899
Liver injuryInsulin receptor substrate 2Q9Y4H2T061289884156; 10371394; 7542850; 8758899
Liver injuryPhosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alphaO00443Not Available9884156; 10371394; 7542850; 8758899
Metabolic disorderGlycogen synthase kinase-3 betaP18266Not Available26096168
Metabolic disorderMitogen-activated protein kinase 1P28482T5897012130710; 12127099; 15229233; 12442202
Metabolic disorderMitogen-activated protein kinase 1P28482T589709884156; 10371394; 7542850; 8758899
Mitochondrial toxicityMitochondrial 2-oxoglutarate/malate carrier proteinQ02978Not Available12939596; 12612910; 10620338
NeurotoxicityGABA receptor subunit B1M9TEZ7Not Available25714970
NeurotoxicityTumor necrosis factorP16599Not Available25845566
NeurotoxicityApoptosis regulator Bcl-2P49950Not Available25714970
NeurotoxicityCytochrome c, somaticP62898Not Available25714970
NeurotoxicityApoptosis regulator BAXG3V8T9Not Available25714970
NeurotoxicityPoly [ADP-ribose] polymerase 1P27008Not Available25714970
NeurotoxicityCaspase-3P55213Not Available25714970
Pancreatic disorderRegenerating islet-derived protein 3-alphaQ06141T920307890213; 7531668; 8119544; 9382059; 16265780; 11912167; 15513386; 10389686
PancreatitisGlutathione S-transferase Mu 1P09488Not Available12794689; 15932176; 15338373
Pancreatitis acuteMyeloperoxidaseP05164T2347112717277; 10714628; 8532655
Pancreatitis chronicD(2) dopamine receptorP14416T6716212376935; 9295055
StuporProenkephalin-AP01210Not Available2823997; 12127099
Toxicity to various agentsCytochrome P450 3A4P08684T37848Not Available
Toxicity to various agentsCytochrome P450 2E1P05181Not AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Erythema23.03.06.001--Not Available
Hyperaesthesia17.02.06.004--Not Available
Hypoaesthesia eye17.02.06.019; 06.01.01.007--Not Available
Hypotension24.06.03.002--
IIIrd nerve paralysis17.04.02.003; 06.05.02.011--Not Available
Meningitis17.06.03.001; 11.01.03.001--
Neuritis17.09.03.001--Not Available
Pain08.01.08.004--
Paraesthesia17.02.06.005--
Skin irritation23.03.04.009--Not Available
Sympathetic nerve injury17.09.02.008; 12.01.12.003--Not Available
Synovial cyst16.18.01.004; 15.04.02.002--Not Available
Femoral nerve palsy17.09.02.005--Not Available
Injection25.01.02.011--Not Available
Neurolysis25.04.02.001--Not Available
Bladder disorder20.03.01.002--Not Available
Erectile dysfunction21.03.01.007; 19.08.04.001--
Rectal obstruction07.13.05.002--
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