Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Nafarelin
Drug ID BADD_D01513
Description Nafarelin is a potent synthetic agonist of gonadotropin-releasing hormone with 3-(2-naphthyl)-D-alanine substitution at residue 6. Nafarelin has been used in the treatments of central precocious puberty and endometriosis.
Indications and Usage For treatment of central precocious puberty (true precocious puberty, GnRH-dependent precocious precocity, complete isosexual precocity) in children of both sexes and for the treatment of endometriosis.
Marketing Status approved
ATC Code H01CA02
DrugBank ID DB00666
KEGG ID D08241
MeSH ID D017274
PubChem ID 25077405
TTD Drug ID D08WYM
NDC Product Code Not Available
UNII 1X0094V6JV
Synonyms Nafarelin | Synarel | RS-94991-298 | RS 94991 298 | RS94991298 | Nafarelin Acetate | Nafarelin Acetate, Hydrate | Nafarelin Monoacetate
Chemical Information
Molecular Formula C66H83N17O13
CAS Registry Number 76932-56-4
SMILES CC(C)CC(C(=O)NC(CCCN=C(N)N)C(=O)N1CCCC1C(=O)NCC(=O)N)NC(=O)C(CC2=CC3=CC=CC=C3C=C 2)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(CO)NC(=O)C(CC5=CNC6=CC=CC=C65)NC(=O)C(CC7=CN=C N7)NC(=O)C8CCC(=O)N8
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal distension07.01.04.001--
Acne23.02.01.001--Not Available
Alopecia23.02.02.001--
Arthralgia15.01.02.001--
Ascites09.01.05.003; 07.07.01.001; 02.05.04.0020.000838%
Asthenia08.01.01.001--Not Available
Bladder pain20.02.02.001--Not Available
Breast atrophy21.05.04.005--
Breast engorgement21.05.05.002; 18.08.02.001--Not Available
Breast enlargement21.05.04.001--Not Available
Breast pain21.05.05.003--
Cerebral infarction17.08.01.004; 24.04.06.0020.000186%Not Available
Cerebrovascular accident24.03.05.001; 17.08.01.007--
Chest pain22.12.02.003; 08.01.08.002; 02.02.02.011--Not Available
Chloasma23.05.01.001; 18.08.02.002--Not Available
Condition aggravated08.01.03.0040.000373%Not Available
Conjunctivitis11.01.06.012; 06.04.01.002--
Constipation07.02.02.001--
Coordination abnormal17.02.02.004--Not Available
Cystitis20.03.02.002; 11.01.14.001--
Depression19.15.01.001--
Dermatitis23.03.04.002--Not Available
Diarrhoea07.02.01.0010.000186%
Dizziness02.11.04.006; 24.06.02.007; 17.02.05.003--
Dry skin23.03.03.001--
Dysgeusia17.02.07.003; 07.14.03.001--
Dyspnoea02.11.05.003; 22.02.01.0040.000279%
Dysuria20.02.02.002--
Ear pain04.03.01.003--
Embolism arterial24.01.01.014--
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