Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Sevoflurane
Drug ID BADD_D02015
Description Sevoflurane, also called fluoromethyl, is an ether inhalation anaesthetic agent used for the induction and maintenance of general anesthesia. It is a volatile, non-flammable, non-irritant, and easy-to-administer compound with a low solubility profile and blood-to-gas partition coefficient.
Indications and Usage Used for induction and maintenance of general anesthesia in adult and pediatric patients for inpatient and outpatient surgery.
Marketing Status Prescription
ATC Code N01AB08
DrugBank ID DB01236
KEGG ID D00547
MeSH ID D000077149
PubChem ID 5206
TTD Drug ID D0W6ZF
NDC Product Code 0074-4456; 10019-651; 0781-6160; 12164-005; 66794-015; 66794-022; 54122-4486; 10019-653; 42677-110; 66794-012; 57884-0036; 12164-009
Synonyms Sevoflurane | Fluoromethyl-2,2,2-trifluoro-1-(trifluoromethyl)ethyl Ether | Fluoromethyl Hexafluoroisopropyl Ether | Sevorane | Ultane | BAX 3084
Chemical Information
Molecular Formula C4H3F7O
CAS Registry Number 28523-86-6
SMILES C(OC(C(F)(F)F)C(F)(F)F)F
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Cognitive disorderGlycine receptor subunit alpha-1P23415T5026925774088
Cognitive disorderApoptosis regulator BAXQ07812T8925125774088
Cognitive disorderApoptosis regulator Bcl-2P10415T3130925774088
Cognitive disorderCaspase-3P42574T5794325774088
Nerve injuryCaspase-3P42574T5794325774088
Nerve injuryApoptosis regulator BAXQ07812T8925125774088
Nerve injuryGlycine receptor subunit alpha-1P23415T5026925774088
Nerve injuryApoptosis regulator Bcl-2P49950Not Available25774088
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Dyspnoea02.01.03.002; 22.02.01.004--
Dystonia17.01.03.0010.002759%Not Available
Dysuria20.02.02.002--
Electrocardiogram QT prolonged13.14.05.0040.006305%
Electrocardiogram ST segment depression13.14.05.0050.000788%Not Available
Electrocardiogram T wave inversion13.14.05.007--Not Available
Electroencephalogram abnormal13.07.03.0010.011428%Not Available
Electrolyte imbalance14.05.01.0020.000788%Not Available
Embolic stroke24.01.04.010; 17.08.01.0320.000788%Not Available
Encephalopathy17.13.02.0010.001182%
Epilepsy17.12.03.0020.000788%Not Available
Extrasystoles02.03.02.003--Not Available
Eyelid oedema10.01.05.001; 06.04.04.004; 23.04.01.003--Not Available
Feeling abnormal08.01.09.014--Not Available
Feeling cold08.01.09.0080.000788%Not Available
Fluoride increased13.17.02.007--Not Available
Fluorosis12.03.01.023--Not Available
Gastrointestinal disorder07.11.01.001--Not Available
Generalised tonic-clonic seizure17.12.01.0020.000788%Not Available
Glycosuria20.02.01.005--
Haemoglobin13.01.05.018--Not Available
Headache17.14.01.001--
Heart rate decreased13.14.04.0010.001182%Not Available
Heart rate increased13.14.04.0020.001576%Not Available
Heart rate irregular13.14.04.0030.000788%Not Available
Hepatic failure09.01.03.0020.000206%
Hepatic function abnormal09.01.02.001--Not Available
Hepatic necrosis09.01.07.002--
Hepatitis09.01.07.004--Not Available
Hepatocellular injury09.01.07.0080.001970%Not Available
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