Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Loperamide
Drug ID BADD_D02428
Description One of the long-acting synthetic antidiarrheals; it is not significantly absorbed from the gut, and has no effect on the adrenergic system or central nervous system, but may antagonize histamine and interfere with acetylcholine release locally.
Indications and Usage For the control and symptomatic relief of acute nonspecific diarrhea and of chronic diarrhea associated with inflammatory bowel disease or gastroenteritis. Also used for reducing the volume of discharge from ileostomies.
Marketing Status Not Available
ATC Code A07DA03
DrugBank ID DB00836
KEGG ID D08144
MeSH ID D008139
PubChem ID 3955
TTD Drug ID D0CS2F
NDC Product Code Not Available
Synonyms Loperamide | R-18553 | R 18553 | R18553 | Imodium | Loperamide Hydrochloride | Hydrochloride, Loperamide | Loperamide Monohydrochloride | Monohydrochloride, Loperamide
Chemical Information
Molecular Formula C29H33ClN2O2
CAS Registry Number 53179-11-6
SMILES CN(C)C(=O)C(CCN1CCC(CC1)(C2=CC=C(C=C2)Cl)O)(C3=CC=CC=C3)C4=CC=CC=C4
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Respiratory depression22.02.01.010; 17.02.05.0470.005192%Not Available
Respiratory failure22.02.06.002; 14.01.04.0030.001483%
Rhabdomyolysis15.05.05.0020.004450%
Seizure17.12.03.0010.007417%
Sinus bradycardia02.03.03.0090.003709%
Somnolence19.02.05.003; 17.02.04.0060.005192%
Suicide attempt19.12.01.0040.001483%
Swelling08.01.03.0150.001483%Not Available
Syncope17.02.04.008; 02.01.02.008; 24.06.02.0120.014834%
Tachycardia02.03.02.0070.007417%Not Available
Torsade de pointes02.03.04.0050.025960%Not Available
Tremor17.01.06.0020.001483%
Unresponsive to stimuli17.02.05.0310.002225%Not Available
Urticaria23.04.02.001; 10.01.06.0010.001483%
Ventricular arrhythmia02.03.04.0060.001161%
Ventricular fibrillation02.03.04.0080.008159%
Ventricular tachycardia02.03.04.0100.031894%
Vomiting07.01.07.0030.008159%
Withdrawal syndrome19.07.02.005; 08.06.02.0120.002967%Not Available
Cardiotoxicity12.03.01.007; 02.01.01.0020.008159%Not Available
Brain oedema17.07.02.003; 12.01.10.0100.000580%
Blood phosphorus increased13.11.01.0160.001483%Not Available
Electrocardiogram T wave abnormal13.14.05.0090.001483%
Ventricular hypokinesia02.04.02.0130.001483%Not Available
Ejection fraction decreased13.14.02.0030.002225%
Haemodynamic instability24.03.02.0060.001483%Not Available
Faecaloma07.01.03.0040.001483%Not Available
Congestive cardiomyopathy02.04.01.0030.002967%Not Available
Brugada syndrome02.03.01.0130.003709%Not Available
Hepatic enzyme increased13.03.01.0190.002225%Not Available
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