Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Ticlopidine hydrochloride
Drug ID BADD_D02216
Description Ticlopidine is an effective inhibitor of platelet aggregation. It is a prodrug that is metabolised to an active form, which blocks the ADP receptor that is involved in GPIIb/IIIa receptor activation leading to platelet aggregation. Ticlopidine is marketed under the brand name Ticlid and is indicated for patients who cannot take aspirin or in whom aspirin has not worked to prevent a thrombotic stroke. The FDA label includes a black-box warning of neutropenia, aplastic anemia, thrombotic thrombocytopenia purpura, and agranulocytosis, so it is necessary to monitor patients' WBC and platelets when they are taking ticlopidine.
Indications and Usage Not Available
Marketing Status Prescription; Discontinued
ATC Code B01AC05
DrugBank ID DB00208
KEGG ID D01028
MeSH ID D013988
PubChem ID 65335
TTD Drug ID D05LBU
NDC Product Code 55486-1565; 49706-0331; 12660-0501
Synonyms Ticlopidine | Ticlopidine Hydrochloride | Hydrochloride, Ticlopidine | Ticlodix | Ticlodone | 53-32C | 53 32C | 5332C | Ticlid
Chemical Information
Molecular Formula C14H15Cl2NS
CAS Registry Number 53885-35-1
SMILES C1CN(CC2=C1SC=C2)CC3=CC=CC=C3Cl.Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Leukaemia01.10.03.001; 16.01.03.001--
Liver function test abnormal13.03.01.013--Not Available
Myositis15.05.01.001--
Nausea07.01.07.001--
Nephrotic syndrome20.05.01.002--
Neuropathy peripheral17.09.03.003--Not Available
Neutropenia01.02.03.004--Not Available
Pain08.01.08.004--
Pancytopenia01.03.03.003--Not Available
Peptic ulcer07.04.07.001--Not Available
Pruritus23.03.12.001--
Purpura24.07.06.005; 23.06.01.004; 01.01.04.003--
Rash23.03.13.001--Not Available
Rash maculo-papular23.03.13.004--
Renal failure20.01.03.005--Not Available
Reticulocytosis01.07.02.002--Not Available
Sepsis11.01.11.003--
Serum sickness12.02.08.004; 10.01.03.004--
Stevens-Johnson syndrome23.03.01.007; 12.03.01.014; 11.07.01.005; 10.01.03.020--
Systemic lupus erythematosus23.03.02.006; 15.06.02.003; 10.04.03.004--Not Available
Thrombocytopenia01.08.01.002--Not Available
Thrombocytosis01.08.02.001--Not Available
Thrombotic thrombocytopenic purpura24.07.06.014; 23.06.01.011; 01.08.01.005--
Tinnitus17.04.07.004; 04.04.01.002--
Urticaria23.04.02.001; 10.01.06.001--
Vasculitis24.05.02.001; 10.02.02.006--
Vomiting07.01.07.003--
Wound haemorrhage12.01.08.017; 24.07.01.029--Not Available
Decreased appetite14.03.01.005; 08.01.09.028--
Bone marrow failure01.03.03.005--
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