Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Promethazine
Drug ID BADD_D01854
Description Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946.[A189901] Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A190153,A190159,A190150,A190171] Promethazine was granted FDA approval before 29 March 1951.[A190177,L4000]
Indications and Usage For the treatment of allergic disorders, and nausea/vomiting.
Marketing Status Prescription; Discontinued
ATC Code D04AA10; R06AD02
DrugBank ID DB01069
KEGG ID D00494
MeSH ID D011398
PubChem ID 4927
TTD Drug ID D0T2XU
NDC Product Code 65162-678; 54348-117
Synonyms Promethazine | Prometazin | Proazamine | Rumergan | Diprazin | Isopromethazine | Phenergan | Phenargan | Phensedyl | Pipolfen | Pipolphen | Promet | Promethazine Hydrochloride | Hydrochloride, Promethazine | Prothazin | Pyrethia | Remsed | Atosil | Diphergan
Chemical Information
Molecular Formula C17H20N2S
CAS Registry Number 60-87-7
SMILES CC(CN1C2=CC=CC=C2SC3=CC=CC=C31)N(C)C
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Drug abuse19.07.02.0100.014892%Not Available
Drug dependence19.07.02.0090.009746%Not Available
Drug hypersensitivity10.01.01.0010.151761%Not Available
Drug withdrawal syndrome19.07.02.011; 08.06.02.0040.005569%Not Available
Dry mouth07.06.01.0020.005569%
Dysarthria19.19.03.001; 17.02.08.0010.009746%
Dyskinesia17.01.02.0060.009746%
Dyspepsia07.01.02.001--
Dysphoria19.04.02.0040.004177%Not Available
Dyspnoea22.02.01.004; 02.01.03.002--
Dyspnoea exertional02.01.03.003; 22.02.01.0050.004177%Not Available
Dystonia17.01.03.0010.016708%Not Available
Electrocardiogram ST segment depression13.14.05.0050.002785%Not Available
Emotional disorder19.04.02.0050.002785%Not Available
Erythema23.03.06.001--Not Available
Euphoric mood19.04.02.006--
Extensor plantar response17.02.01.0050.004177%Not Available
Extrapyramidal disorder17.01.02.007--
Extrasystoles02.03.02.0030.011138%Not Available
Extravasation08.01.03.0080.005569%Not Available
Fatigue08.01.01.002--
Fear19.06.03.0010.002785%Not Available
Feeling abnormal08.01.09.0140.011138%Not Available
Flushing24.03.01.002; 23.06.05.003; 08.01.03.0250.004177%
Gallbladder disorder09.03.02.0010.004177%Not Available
Gangrene24.04.05.003; 23.06.06.001; 11.02.01.0030.004177%Not Available
Generalised tonic-clonic seizure17.12.01.0020.002785%Not Available
Hallucination19.10.02.0020.020885%
Hallucination, visual19.10.02.0040.008354%Not Available
Headache17.14.01.001--
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