Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Loxapine
Drug ID BADD_D01326
Description An antipsychotic agent used in schizophrenia. [PubChem]
Indications and Usage For the management of the manifestations of psychotic disorders such as schizophrenia
Marketing Status Prescription; Discontinued
ATC Code N05AH01
DrugBank ID DB00408
KEGG ID D02340
MeSH ID D008152
PubChem ID 3964
TTD Drug ID D0U5OE
NDC Product Code 0527-1395; 64850-891; 70518-1896; 0527-1397; 35573-438; 0591-0371; 70518-0346; 70518-2120; 0527-1396; 35573-437; 0527-1394; 64850-893; 0591-0372; 0591-0369; 70518-0416; 35573-436; 0591-0370; 64850-890; 64850-892; 70518-1681; 53296-0095; 50090-4701; 70518-0283; 35573-439; 70518-0347
Synonyms Loxapine | 2-Chloro-11-(4-methyl-1-piperazinyl)-dibenz(b,f)(1,4)oxazepine | Oxilapine | Cloxazepine | Loxapine Hydrochloride | Hydrochloride, Loxapine | Loxitane | Loxapine Succinate | Succinate, Loxapine | Loxapinsuccinate | Loxipine Succinate | Loxipine Maleate | Maleate, Loxipine | CL-71,563 | CL 71,563 | CL71,563 | Loxapine Monohydrochloride
Chemical Information
Molecular Formula C18H18ClN3O
CAS Registry Number 1977-10-2
SMILES CN1CCN(CC1)C2=NC3=CC=CC=C3OC4=C2C=C(C=C4)Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Flushing24.03.01.002; 23.06.05.003; 08.01.03.025--
Gait disturbance17.02.05.016; 08.01.02.002--
Galactorrhoea21.05.02.002; 05.03.04.002--Not Available
Gastrointestinal disorder07.11.01.001--Not Available
Glaucoma06.03.01.002--
Gynaecomastia21.05.04.003; 05.05.02.003--
Headache17.14.01.001--
Hepatitis09.01.07.004--Not Available
Hepatocellular injury09.01.07.008--Not Available
Hyperpyrexia08.05.02.002--Not Available
Hypersensitivity10.01.03.003--
Hypertension24.08.02.001--
Hypoaesthesia17.02.06.023--Not Available
Hypotension24.06.03.002--
Ileus paralytic07.02.05.001--Not Available
Insomnia19.02.01.002; 17.15.03.002--
Jaundice23.03.03.030; 09.01.01.004; 01.06.04.004--Not Available
Leukopenia01.02.02.001--Not Available
Loss of consciousness17.02.04.004--Not Available
Masked facies17.01.05.007--Not Available
Menstruation irregular21.01.01.005; 05.05.01.008--
Muscle rigidity17.05.02.005; 15.05.04.001--Not Available
Muscle spasms15.05.03.004--
Muscle twitching15.05.03.005--Not Available
Nasal congestion22.04.04.001--
Nausea07.01.07.001--
Nervous system disorder17.02.10.001--Not Available
Neuroleptic malignant syndrome17.05.02.003; 15.05.04.015; 12.03.01.003; 08.05.01.005--Not Available
Oculogyric crisis17.01.03.002; 06.05.02.002--Not Available
Oedema08.01.07.006; 14.05.06.010--Not Available
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