Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Carmustine
Drug ID BADD_D00371
Description A cell-cycle phase nonspecific alkylating antineoplastic agent. It is used in the treatment of brain tumors and various other malignant neoplasms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p462) This substance may reasonably be anticipated to be a carcinogen according to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (From Merck Index, 11th ed)
Indications and Usage For the treatment of brain tumors, multiple myeloma, Hodgkin's disease and Non-Hodgkin's lymphomas.
Marketing Status Prescription
ATC Code L01AD01
DrugBank ID DB00262
KEGG ID D00254
MeSH ID D002330
PubChem ID 2578
TTD Drug ID D01OXI
NDC Product Code 70121-1482; 50683-0017; 76339-121; 0781-3474; 59651-168; 24338-050; 68475-503; 54893-0055; 23155-649; 57821-002; 55718-139; 23155-790; 43598-628; 59981-034; 70710-1525; 58621-002; 57884-0032; 54879-036; 23155-261; 71288-126
Synonyms Carmustine | BCNU | N,N'-Bis(2-Chloroethyl)-N-Nitrosourea | FIVB | 1,3-Bis(2-Chloroethyl)-1-Nitrosourea | BiCNU | Nitrumon
Chemical Information
Molecular Formula C5H9Cl2N3O2
CAS Registry Number 154-93-8
SMILES C(CCl)NC(=O)N(CCCl)N=O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
GliomaMethylated-DNA--protein-cysteine methyltransferaseP16455T2458711070098; 15297393; 12744471
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Generalised tonic-clonic seizure17.12.01.002--Not Available
Gynaecomastia21.05.04.003; 05.05.02.003--
Haemoglobin13.01.05.018--Not Available
Haemorrhage intracranial24.07.04.003; 17.08.01.0080.000139%
Hallucination19.10.02.002--
Headache17.14.01.0010.002398%
Hemiparesis17.01.04.0010.000799%
Hemiplegia17.01.04.0020.007726%Not Available
Hepatic function abnormal09.01.02.0010.000799%Not Available
Hepatotoxicity09.01.07.009; 12.03.01.008--Not Available
Hydrocephalus17.07.01.0010.000799%
Hyperaemia24.03.02.002--Not Available
Hyperglycaemia14.06.02.002; 05.06.02.002--
Hypersensitivity10.01.03.003--
Hypertension24.08.02.0010.001066%
Hypoaesthesia17.02.06.023--Not Available
Hypokalaemia14.05.03.002--
Hypokinesia17.01.02.009--Not Available
Hyponatraemia14.05.04.0020.000533%
Hypotension24.06.03.002--
IIIrd nerve paralysis17.04.02.003; 06.05.02.0110.000533%Not Available
Impaired healing08.03.02.001--Not Available
Infection11.01.08.0020.002131%Not Available
Infertility21.03.02.001--Not Available
Injection site pain08.02.03.010; 12.07.03.011--Not Available
Injection site reaction12.07.03.015; 08.02.03.014--
Injury12.01.08.004--Not Available
Insomnia19.02.01.002; 17.15.03.002--
Interstitial lung disease22.01.02.003; 10.02.01.033--Not Available
Intracranial pressure increased17.07.02.0020.001332%Not Available
The 3th Page    First    Pre   3 4 5 6 7    Next   Last    Total 7 Pages