Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Cytokine release syndrome
ADR ID BADD_A05078
ADR Hierarchy
10      Immune system disorders
10.02      Immune disorders NEC
10.02.01      Immune and associated conditions NEC
10.02.01.010      Cytokine release syndrome
Description A disorder characterized by fever, tachypnea, headache, tachycardia, hypotension, rash, and/or hypoxia caused by the release of cytokines. [CTCAE]
MedDRA Code 10052015
MeSH ID Not Available
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE)
Synonym
Cytokine release syndrome
ADR Related Proteins
Protein Name UniProt AC TTD Target ID
Interleukin-1 betaP01584T42000
Interleukin-6P05231T32578
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00214Basiliximab--
BADD_D00282Blinatumomab--
BADD_D00284Bortezomib0.000533%
BADD_D00429Chlorambucil0.000139%
BADD_D00589Dasatinib0.000533%
BADD_D00623Dexamethasone0.003776%
BADD_D00914Fludarabine0.007726%
BADD_D01136Imatinib0.001066%
BADD_D01253Lenalidomide--
BADD_D01265Levetiracetam0.001904%
BADD_D01435Methylprednisolone hemisuccinate0.013989%
BADD_D01445Metoprolol0.000047%
BADD_D01506Muromonab-cd3--
BADD_D01596Ofatumumab--
BADD_D01633Oxaliplatin0.004529%
BADD_D01858Propagermanium--
BADD_D01953Rituximab--
BADD_D02392Zoledronic acid0.013122%
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