Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Chlorambucil
Drug ID BADD_D00429
Description A nitrogen mustard alkylating agent used as antineoplastic agent for the treatment of various malignant and nonmalignant diseases. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
Indications and Usage For treatment of chronic lymphatic (lymphocytic) leukemia, childhood minimal-change nephrotic syndrome, and malignant lymphomas including lymphosarcoma, giant follicular lymphoma, Hodgkin's disease, non-Hodgkin's lymphomas, and Waldenström’s Macroglobulinemia.
Marketing Status Prescription
ATC Code L01AA02
DrugBank ID DB00291
KEGG ID D00266
MeSH ID D002699
PubChem ID 2708
NDC Product Code 71052-212; 76055-0025; 76388-635; 72969-010; 50683-0384; 49452-1911; 43744-066
Synonyms Chlorambucil | 4-(Bis(2-chloroethyl)amino)benzenebutanoic Acid | N,N-Di-(2-chloroethyl)-p-aminophenylbutyric Acid | Chloraminophene | Chlorbutin | NSC-3088 | NSC 3088 | NSC3088 | Leukeran | Lympholysin | Amboclorin | CB-1348 | CB 1348 | CB1348
Chemical Information
Molecular Formula C14H19Cl2NO2
CAS Registry Number 305-03-3
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Abdominal pain upper07.01.05.0030.000799%
Acute hepatic failure09.01.03.0010.000139%Not Available
Acute respiratory failure22.02.06.001; Available
Aggression19.05.01.0010.000533%Not Available
Agranulocytosis01.02.03.0010.000799%Not Available
Anaphylactic reaction24.06.03.006;
Angina pectoris24.04.04.002;
Angioedema23.04.01.001; Available
Aspartate aminotransferase increased13.03.01.0060.001332%
Asthenia08.01.01.001--Not Available
Atrial fibrillation02.03.03.0020.000533%
Bladder pain20.02.02.001--Not Available
Blood creatinine increased13.13.01.0040.000533%
Blood lactate dehydrogenase increased13.04.02.0020.001066%
Blood pressure decreased13.14.03.0020.000533%Not Available
Blood urea increased13.13.01.0060.000533%Not Available
Blood uric acid increased13.02.04.001--Not Available
Body temperature increased13.15.01.001--Not Available
C-reactive protein increased13.09.01.0070.000533%Not Available
Cerebral haemorrhage24.07.04.001; Available
Chest pain02.02.02.011;; Available
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