Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Lorazepam
Drug ID BADD_D01318
Description Lorazepam is a short-acting and rapidly cleared benzodiazepine used commonly as a sedative and anxiolytic.[A957] It was developed by DJ Richards, presented and marketed initially by Wyeth Pharmaceuticals in the USA in 1977. The first historic FDA label approval is reported in 1985 by the company Mutual Pharm.[L5095]
Indications and Usage For the management of anxiety disorders, and for treatment of status epilepticus.
Marketing Status Prescription; Discontinued
ATC Code N05BA06
DrugBank ID DB00186
KEGG ID D00365
MeSH ID D008140
PubChem ID 3958
TTD Drug ID D0E0OG
NDC Product Code 55700-778; 0904-6009; 55289-402; 53002-7721; 52427-663; 0641-6046; 0641-6051; 72572-380; 0409-6778; 60687-638; 68071-5068; 0591-0242; 60687-401; 54348-049; 53002-5291; 69315-905; 76329-8261; 70518-2239; 68788-7480; 52696-0002; 0093-3425; 53002-5290; 61919-607; 13107-085; 0641-6048; 70518-2442; 55289-487; 68071-5137; 51927-1005; 0641-6207; 71610-600; 72166-001; 54348-028; 0641-6003; 71610-122; 67296-1332; 0591-0241; 43063-048; 43063-057; 55154-7976; 0409-6779; 0904-6007; 69315-906; 63629-8185; 0641-6047; 12828-0025; 67296-1629; 71610-178; 55700-745; 70518-1520; 68788-7428; 0641-6049; 65162-017; 70518-0486; 71610-255; 68071-2666; 0641-6001; 50090-0273; 70518-3225; 0409-1985; 76420-296; 45865-499; 67544-142; 0615-8077; 65162-018; 0641-6044; 48087-0076; 65162-015; 50090-0272; 50090-4001; 0409-1539; 68071-5084; 51927-0195; 0409-6780; 71610-199; 52427-667; 0615-8075; 72789-197; 50090-5508; 67296-1622; 60687-355; 67763-101; 50383-705; 68071-5022; 0641-6000; 49452-4140; 71205-228; 58118-1095; 63187-536; 68788-7533; 71335-0655; 13107-084; 13107-083; 70518-3188; 71205-166; 61919-062; 63629-2953; 68071-5061; 68071-5048; 71335-0329; 58118-1096; 70518-0445; 0591-0240; 0641-6045; 71610-229; 0641-6050; 62991-1682; 69315-904; 71335-1694; 68071-4882; 0054-3532; 63187-576; 71554-009; 53002-6290; 50090-4191; 68071-3096; 58118-0904; 60760-516; 50090-4157; 50090-5509; 60687-627; 71335-1467; 0187-0065; 72789-236; 17856-2059; 52427-661; 72789-226; 0093-3426; 50090-5081; 43353-255; 68071-4918; 71610-008; 0641-6002; 68071-3242; 71335-1138; 70518-2268; 68071-3227; 0093-3427; 68788-7355; 68071-2662; 63275-9979; 0121-0770; 0615-8076; 67544-191; 38779-0927; 0395-8161; 68071-4916; 70518-2186; 71610-225; 55154-7975; 70518-0275; 52427-658; 68071-5250; 50090-2810; 17478-040; 60687-649; 65162-687; 0187-0063; 51552-0729; 64330-020; 71205-235; 68071-3121; 67296-0143; 50090-3462; 67544-261; 17856-3532; 0904-6008; 57218-950; 0187-0064
Synonyms Lorazepam | Ativan | Orfidal Wyeth | Wyeth, Orfidal | Témesta | Tolid | Donix | Duralozam | Durazolam | Idalprem | Laubeel | Lorazep Von Ct | Von Ct, Lorazep | Lorazepam Medical | Medical, Lorazepam | Lorazepam-Neuraxpharm | Lorazepam Neuraxpharm | Lorazepam-Ratiopharm | Lorazepam Ratiopharm | Novo-Lorazem | Novo Lorazem | Nu-Loraz | Nu Loraz | Sedicepan | Sinestron | WY-4036 | WY 4036 | WY4036 | Apo-Lorazepam | Apo Lorazepam | Somagerol | Temesta
Chemical Information
Molecular Formula C15H10Cl2N2O2
CAS Registry Number 846-49-1
SMILES C1=CC=C(C(=C1)C2=NC(C(=O)NC3=C2C=C(C=C3)Cl)O)Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001--Not Available
Abdominal distension07.01.04.001--
Abdominal pain07.01.05.002--
Abdominal pain upper07.01.05.003--
Abnormal dreams19.02.03.001; 17.15.02.0010.000134%Not Available
Acidosis14.01.03.0020.000201%
Acute hepatic failure09.01.03.0010.000134%Not Available
Acute myocardial infarction24.04.04.001; 02.02.02.001--Not Available
Acute respiratory distress syndrome22.01.03.0010.000035%
Aggression19.05.01.0010.001007%Not Available
Agitation19.06.02.001; 17.02.05.0120.003892%
Agranulocytosis01.02.03.001--Not Available
Akathisia19.06.02.006; 17.01.02.0020.000201%
Alanine aminotransferase increased13.03.01.0030.000537%
Alcohol abuse19.07.02.0070.000134%Not Available
Alopecia23.02.02.001--
Altered state of consciousness17.02.04.001; 19.07.01.0030.000738%Not Available
Amnesia19.20.01.001; 17.03.02.0010.000805%
Amylase increased13.05.01.0090.000201%
Anaemia01.03.02.001--
Anaesthetic complication pulmonary12.02.12.007; 22.02.07.0050.000201%Not Available
Anaphylactic reaction24.06.03.006; 10.01.07.0010.000537%
Anger19.04.02.0010.000403%Not Available
Anterograde amnesia19.20.01.005; 17.03.02.005--Not Available
Anxiety19.06.02.0020.002282%
Aortic dissection24.02.03.0020.000134%Not Available
Aphasia19.21.01.001; 17.02.03.0010.000403%
Aphthous ulcer07.05.06.0020.000201%Not Available
Apnoea22.02.01.0010.000105%
Application site pain12.07.01.004; 08.02.01.004--Not Available
The 1th Page    1 2 3 4 5    Next   Last    Total 16 Pages