Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Porphyria non-acute
ADR ID BADD_A03512
ADR Hierarchy
03      Congenital, familial and genetic disorders
03.08      Metabolic and nutritional disorders congenital
03.08.01      Inborn errors of porphyrin metabolism
03.08.01.004      Porphyria non-acute
09      Hepatobiliary disorders
09.01      Hepatic and hepatobiliary disorders
09.01.10      Hepatic metabolic disorders
09.01.10.003      Porphyria non-acute
14      Metabolism and nutrition disorders
14.14      Inborn errors of metabolism
14.14.01      Inborn errors of porphyrin metabolism
14.14.01.004      Porphyria non-acute
23      Skin and subcutaneous tissue disorders
23.03      Epidermal and dermal conditions
23.03.01      Bullous conditions
23.03.01.012      Porphyria non-acute
Description An autosomal dominant porphyria that is due to a deficiency of FERROCHELATASE (heme synthetase) in both the LIVER and the BONE MARROW, the last enzyme in the 8-enzyme biosynthetic pathway of HEME. Clinical features include mainly neurological symptoms, rarely cutaneous lesions, and elevated levels of protoporphyrin and COPROPORPHYRINS in the feces. [MeSH]
MedDRA Code 10036186
MeSH ID D046351; D017119
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Cutaneous hepatic porphyria | Erythropoietic protoporphyria | Hematoporphyrinemia | Porphyria cutanea tarda | Porphyria hepatic | Porphyria hepatic aggravated | Porphyria non-acute | Porphyria non-acute aggravated | Haematoporphyrinaemia | Uroporphyrinogen decarboxylase deficiency | Protoporphyria, Erythropoietic | Erythropoietic Protoporphyrias | Protoporphyrias, Erythropoietic | Erythrohepatic Protoporphyria | Erythropoietic Protoporphyria | Ferrochelatase Deficiency | Deficiencies, Ferrochelatase | Deficiency, Ferrochelatase | Ferrochelatase Deficiencies | Heme Synthetase Deficiency | Deficiencies, Heme Synthetase | Deficiency, Heme Synthetase | Heme Synthetase Deficiencies | Synthetase Deficiencies, Heme | Synthetase Deficiency, Heme
ADR Related Proteins
Protein Name UniProt AC TTD Target ID
Not AvailableNot AvailableNot Available
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00076Allopurinol0.000132%
BADD_D00277Bisoprolol0.003354%
BADD_D00283Boceprevir--
BADD_D00318Busulfan--
BADD_D00356Carbamazepine--
BADD_D00447Chlorpropamide--
BADD_D00821Estradiol--
BADD_D01022Gliclazide--
BADD_D01023Glimepiride--
BADD_D01024Glipizide--
BADD_D01030Glyburide--
BADD_D01285Levothyroxine0.000023%
BADD_D01533Naproxen--
BADD_D01534Naproxen sodium--
BADD_D01596Ofatumumab--
BADD_D01933Ribavirin0.253833%
BADD_D02111Tamoxifen--
BADD_D02112Tamoxifen citrate--
BADD_D02238Tolazamide--
BADD_D02240Tolbutamide--
BADD_D02244Tolterodine0.001541%
BADD_D02329Valproic acid0.000443%
BADD_D02369Voriconazole0.039934%
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