Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Rifampicin
Drug ID BADD_D01936
Description A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation of RNA synthesis. Rifampin is bactericidal, and acts on both intracellular and extracellular organisms. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1160)
Indications and Usage For the treatment of Tuberculosis and Tuberculosis-related mycobacterial infections.
Marketing Status approved
ATC Code J04AB02
DrugBank ID DB01045
KEGG ID D00211
MeSH ID D012293
PubChem ID 135398735
TTD Drug ID D0G3DL
NDC Product Code 73005-0006
UNII VJT6J7R4TR
Synonyms Rifampin | Benemycin | Rifampicin | Rimactan | Tubocin | Rifadin | Rimactane
Chemical Information
Molecular Formula C43H58N4O12
CAS Registry Number 13292-46-1
SMILES CC1C=CC=C(C(=O)NC2=C(C(=C3C(=C2O)C(=C(C4=C3C(=O)C(O4)(OC=CC(C(C(C(C(C(C1O)C)O)C) OC(=O)C)C)OC)C)C)O)O)C=NN5CCN(CC5)C)C
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Blood pressure inadequately controlled24.06.01.0070.001867%Not Available
Necrotising colitis07.08.01.0130.001867%Not Available
Lymphatic disorder01.09.01.003--Not Available
Type IV hypersensitivity reaction10.01.03.0220.023145%Not Available
Drug resistance08.06.01.0050.014373%Not Available
Adverse event08.06.01.0100.006346%Not Available
Connective tissue disorder10.04.04.026; 15.06.01.006--Not Available
Infestation23.11.01.002; 11.09.01.001--Not Available
Porphyrin metabolism disorder14.14.01.006; 09.01.10.004; 03.08.01.006--Not Available
Abnormal behaviour19.01.01.001--Not Available
Decreased appetite14.03.01.005; 08.01.09.028--
Renal injury20.01.03.015; 12.01.05.0010.001867%Not Available
Blood disorder01.05.01.004--Not Available
Adverse drug reaction08.06.01.0090.005040%Not Available
Disease recurrence08.01.03.0500.004666%Not Available
Drug intolerance08.06.01.0130.023145%Not Available
Psychotic disorder19.03.01.002--
Hepatobiliary disease09.01.08.003--Not Available
Immunosuppression10.03.02.001--Not Available
Renal impairment20.01.03.0100.001867%Not Available
Bone marrow failure01.03.03.0050.001867%
Mixed liver injury09.01.07.0150.001867%Not Available
Treatment failure08.06.01.017--Not Available
Liver injury12.01.17.012; 09.01.07.022--Not Available
Low birth weight baby18.04.02.0030.003733%Not Available
Acute kidney injury20.01.03.0160.023145%
Drug-induced liver injury12.03.01.044; 09.01.07.0230.006906%Not Available
Drug reaction with eosinophilia and systemic symptoms12.03.01.064; 23.03.05.005; 10.01.01.0210.024265%Not Available
IgA nephropathy20.05.01.016; 10.02.01.0630.001867%Not Available
Drug ineffective for unapproved indication12.09.02.002; 08.06.01.0380.005040%Not Available
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ADReCS-Target
Drug Name ADR Term Target
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