Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Pyrazinamide
Drug ID BADD_D01880
Description A pyrazine that is used therapeutically as an antitubercular agent.
Indications and Usage For the initial treatment of active tuberculosis in adults and children when combined with other antituberculous agents.
Marketing Status approved; investigational
ATC Code J04AK01
DrugBank ID DB00339
KEGG ID D00144
MeSH ID D011718
PubChem ID 1046
TTD Drug ID D0XF8W
NDC Product Code 66639-165; 11712-815; 61748-012; 70954-484; 50090-0520; 70518-3661; 70518-2534; 50090-5963; 33342-447
UNII 2KNI5N06TI
Synonyms Pyrazinamide | Tisamid
Chemical Information
Molecular Formula C5H5N3O
CAS Registry Number 98-96-4
SMILES C1=CN=C(C=N1)C(=O)N
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Epilepsy17.12.03.0020.001540%Not Available
Feeling abnormal08.01.09.014--Not Available
Gastrointestinal disorder07.11.01.0010.001027%Not Available
Gout14.09.01.001; 15.01.06.001--Not Available
Gouty arthritis15.01.06.004; 14.09.01.004--Not Available
Headache17.14.01.0010.003594%
Hepatic failure09.01.03.0020.001027%
Hepatic function abnormal09.01.02.0010.001027%Not Available
Hepatitis09.01.07.0040.001027%Not Available
Hepatitis toxic12.03.01.016; 09.01.07.0170.005135%Not Available
Hepatocellular injury09.01.07.0080.001540%Not Available
Hepatomegaly09.01.05.001--Not Available
Hepatotoxicity12.03.01.008; 09.01.07.0090.002054%Not Available
Hypersensitivity10.01.03.003--
Hypersensitivity vasculitis24.12.04.013; 23.06.02.005; 10.02.02.017; 01.01.04.0080.001027%Not Available
Hyperuricaemia14.09.01.0030.001027%
Hyponatraemia14.05.04.0020.001027%
Insomnia19.02.01.002; 17.15.03.0020.001540%
Jaundice23.03.03.030; 09.01.01.004; 01.06.04.0040.001027%Not Available
Leukopenia01.02.02.0010.001027%Not Available
Liver tenderness09.01.05.004--Not Available
Lymphadenopathy01.09.01.0020.002054%Not Available
Malaise08.01.01.0030.001540%
Marrow hyperplasia16.21.01.001; 01.13.01.001--Not Available
Muscle spasms15.05.03.0040.001027%
Myalgia15.05.02.001--
Nausea07.01.07.0010.006675%
Neuropathy peripheral17.09.03.0030.001540%Not Available
Pain08.01.08.0040.002567%
Pancytopenia01.03.03.0030.001027%Not Available
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