Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Pyrazinamide
Drug ID BADD_D01880
Description A pyrazine that is used therapeutically as an antitubercular agent.
Indications and Usage For the initial treatment of active tuberculosis in adults and children when combined with other antituberculous agents.
Marketing Status Prescription
ATC Code J04AK01
DrugBank ID DB00339
KEGG ID D00144
MeSH ID D011718
PubChem ID 1046
TTD Drug ID D0XF8W
NDC Product Code 70518-2534; 66639-165; 70954-484; 61748-012; 33342-447; 50090-0520; 0904-6696; 11712-815; 49452-6135; 50090-0521; 71052-311
Synonyms Pyrazinamide | Tisamid
Chemical Information
Molecular Formula C5H5N3O
CAS Registry Number 98-96-4
SMILES C1=CN=C(C=N1)C(=O)N
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Dysuria20.02.02.002--
Electrocardiogram QT prolonged13.14.05.0040.004591%
Eosinophilia01.02.04.0010.004591%
Epilepsy17.12.03.0020.006887%Not Available
Fatigue08.01.01.0020.006887%
Feeling abnormal08.01.09.014--Not Available
Gamma-glutamyltransferase increased13.03.01.0110.004591%
Gastrointestinal disorder07.11.01.0010.004591%Not Available
Gout15.01.06.001; 14.09.01.001--Not Available
Gouty arthritis15.01.06.004; 14.09.01.004--Not Available
Headache17.14.01.0010.011478%
Hepatitis09.01.07.0040.001198%Not Available
Hepatocellular injury09.01.07.0080.004591%Not Available
Hepatomegaly09.01.05.001--Not Available
Hepatotoxicity09.01.07.009; 12.03.01.0080.006887%Not Available
Hypersensitivity10.01.03.003--
Hypersensitivity vasculitis24.05.02.012; 23.06.02.005; 10.02.02.017; 01.01.04.0080.004591%Not Available
Hyperuricaemia14.09.01.0030.004591%
Hyponatraemia14.05.04.0020.006887%
Insomnia17.15.03.002; 19.02.01.0020.006887%
Jaundice23.03.03.030; 09.01.01.004; 01.06.04.0040.004591%Not Available
Liver tenderness09.01.05.004--Not Available
Lymphadenopathy01.09.01.0020.009182%Not Available
Malaise08.01.01.0030.006887%
Marrow hyperplasia16.21.01.001; 01.13.01.001--Not Available
Myalgia15.05.02.0010.004591%
Nausea07.01.07.0010.027546%
Neuropathy peripheral17.09.03.0030.006887%Not Available
Pain08.01.08.0040.011478%
Pancytopenia01.03.03.0030.004591%Not Available
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