Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Propylthiouracil
Drug ID BADD_D01869
Description A thiourea antithyroid agent. Propythiouracil inhibits the synthesis of thyroxine and inhibits the peripheral conversion of throxine to tri-iodothyronine. It is used in the treatment of hyperthyroidism. (From Martindale, The Extra Pharmacopeoia, 30th ed, p534)
Indications and Usage Used to manage hyperthyroidism which is due to an overactive thyroid gland (Grave's disease).
Marketing Status Prescription; Discontinued
ATC Code H03BA02
DrugBank ID DB00550
KEGG ID D00562
MeSH ID D011441
PubChem ID 657298
TTD Drug ID D00MIN
NDC Product Code 20012-0001; 49452-6112; 65319-1059; 68084-964; 51927-0163; 51927-1183; 59348-0013; 70752-171; 67253-651; 0228-2348
Synonyms Propylthiouracil | 6-Propyl-2-Thiouracil | 6 Propyl 2 Thiouracil
Chemical Information
Molecular Formula C7H10N2OS
CAS Registry Number 51-52-5
SMILES CCCC1=CC(=O)NC(=S)N1
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
VasculitisMitochondrial substrate carrier family protein ancAO97470Not Available9181282; 11250767; 8103148; 15746603; 15473130; 15138182; 12507274; 15730621
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Low birth weight baby18.04.02.0030.010931%Not Available
Traumatic liver injury12.01.02.008; 09.01.08.010--Not Available
Acute kidney injury20.01.03.0160.027327%
Drug-induced liver injury12.03.01.044; 09.01.07.0230.016396%Not Available
Granulomatosis with polyangiitis24.05.02.013; 22.01.01.015; 20.05.01.013; 10.02.02.0180.016396%Not Available
Multiple organ dysfunction syndrome08.01.03.0570.007129%
Cryoglobulinaemia24.05.02.019; 10.04.04.0130.016396%Not Available
Goitre congenital05.02.01.004; 03.09.03.0020.016396%Not Available
Maternal drugs affecting foetus18.03.03.009; 12.03.03.0060.016396%Not Available
Anti-neutrophil cytoplasmic antibody positive vasculitis24.05.02.016; 10.02.02.0230.174891%Not Available
Escherichia infection11.02.10.0040.002851%Not Available
Pulmonary renal syndrome22.01.01.022; 20.05.01.019; 10.04.04.0170.038257%Not Available
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