Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Ponatinib
Drug ID BADD_D01799
Description Ponatinib is a novel Bcr-Abl tyrosine kinase inhibitor that is especially effective against the T315I mutation for the treatment of chronic myeloid leukemia. FDA approved on December 14, 2012.
Indications and Usage Ponatinib is indicated for the treatment of adult patients with chronic phase, accelerated phase, or blast phase chronic myeloid leukemia (CML) that is resistant or intolerant to prior tyrosine kinase inhibitor therapy or Philadelphia chromosome positive acute lymphoblastic leukemia (Ph+ALL) that is resistant or intolerant to prior tyrosine kinase inhibitor therapy.
Marketing Status Prescription
ATC Code L01EA05
DrugBank ID DB08901
KEGG ID D09950
MeSH ID C545373
PubChem ID 24826799
TTD Drug ID D0H0EQ
NDC Product Code Not Available
Synonyms ponatinib | 3-(2-(imidazo(1,2-b)pyridazin-3-yl)ethynyl)-4-methyl-N-(4-((4-methylpiperazin-y-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide | ponatinib hydrochloride | AP24534 | AP-24534 | AP 24534 | Iclusig
Chemical Information
Molecular Formula C29H27F3N6O
CAS Registry Number 943319-70-8
SMILES CC1=C(C=C(C=C1)C(=O)NC2=CC(=C(C=C2)CN3CCN(CC3)C)C(F)(F)F)C#CC4=CN=C5N4N=CC=C5
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Gamma-glutamyltransferase increased13.03.01.011--
Gastric haemorrhage24.07.02.007; 07.12.01.001--
Gastritis07.08.02.0010.000533%
Gastrooesophageal reflux disease07.02.02.0030.000533%
Gastrointestinal disorder07.11.01.001--Not Available
Gastrointestinal haemorrhage24.07.02.009; 07.12.02.001--Not Available
Gastrointestinal pain07.01.05.005--
Generalised oedema08.01.07.004; 14.05.06.0070.000533%
Generalised tonic-clonic seizure17.12.01.0020.000533%Not Available
Gout15.01.06.001; 14.09.01.0010.000799%Not Available
Graft versus host disease12.02.09.001; 10.02.01.0270.000556%Not Available
Haematuria24.07.01.047; 20.02.01.0060.000799%
Haemoglobin13.01.05.018--Not Available
Haemoglobin decreased13.01.05.003--Not Available
Headache17.14.01.0010.009058%
Heart rate increased13.14.04.0020.000799%Not Available
Hemiplegia17.01.04.0020.000533%Not Available
Hepatic cirrhosis09.01.04.0010.000139%Not Available
Hepatic failure09.01.03.0020.000139%
Hepatic function abnormal09.01.02.0010.000533%Not Available
Hepatomegaly09.01.05.0010.000799%Not Available
Hepatosplenomegaly09.01.05.002; 01.09.03.0010.000799%Not Available
Hepatotoxicity09.01.07.009; 12.03.01.0080.001598%Not Available
Herpes zoster23.09.03.002; 11.05.02.0030.000799%
Hyperaesthesia17.02.06.0040.000533%Not Available
Hyperbilirubinaemia01.06.04.003; 14.11.01.010; 09.01.01.0030.000533%Not Available
Hypercalcaemia14.04.01.003; 05.04.01.002--
Hypercholesterolaemia14.08.01.0010.000533%Not Available
Hyperglycaemia14.06.02.002; 05.06.02.0020.000533%
Hyperhidrosis23.02.03.004; 08.01.03.028--
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