Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Lomustine
Drug ID BADD_D01313
Description An alkylating agent of value against both hematologic malignancies and solid tumors.
Indications and Usage For the treatment of primary and metastatic brain tumors as a component of combination chemotherapy in addition to appropriate surgical and/or radiotherapeutic procedures. Also used in combination with other agents as secondary therapy for the treatment of refractory or relapsed Hodgkin's disease.
Marketing Status Prescription
ATC Code L01AD02
DrugBank ID DB01206
KEGG ID D00363
MeSH ID D008130
PubChem ID 3950
TTD Drug ID D04JPJ
NDC Product Code 43744-331; 58181-3042; 71052-171; 55111-965; 58181-3041; 58181-3040; 72969-040
Synonyms Lomustine | NSC-79037 | NSC 79037 | NSC79037 | Cecenu | CeeNU | Belustine | CCNU
Chemical Information
Molecular Formula C9H16ClN3O2
CAS Registry Number 13010-47-4
SMILES C1CCC(CC1)NC(=O)N(CCCl)N=O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Neutropenia01.02.03.0040.000533%Not Available
Optic atrophy06.09.02.001--Not Available
Osteoarthritis15.01.04.001--Not Available
Pain08.01.08.0040.000533%
Pancytopenia01.03.03.003--Not Available
Paraesthesia17.02.06.0050.000799%
Platelet count decreased13.01.04.0010.001865%
Pneumonia22.07.01.003; 11.01.09.0030.000799%Not Available
Pulmonary fibrosis22.01.02.006--
Renal failure20.01.03.005--Not Available
Seizure17.12.03.0010.001865%
Stomatitis07.05.06.005--
Thrombocytopenia01.08.01.0020.001066%Not Available
Visual impairment06.02.06.008--Not Available
Vomiting07.01.07.0030.000799%
White blood cell count abnormal13.01.06.0280.000533%Not Available
White blood cell count decreased13.01.06.0120.001598%
Contusion23.03.11.002; 15.03.01.008; 12.01.06.001; 24.07.06.001--
Bone marrow toxicity12.03.01.006; 01.03.03.0040.000533%Not Available
Transaminases increased13.03.01.015--Not Available
Haemorrhage24.07.01.002--Not Available
Dysplasia08.03.04.007--Not Available
Gastrointestinal toxicity12.03.01.019; 07.08.03.006--Not Available
Blood alkaline phosphatase increased13.04.02.004--
Neurological symptom17.02.05.010--Not Available
Haematotoxicity12.03.01.025; 01.05.01.0070.000533%Not Available
Neoplasm progression16.16.02.0050.000139%Not Available
Decreased appetite14.03.01.005; 08.01.09.028--
Renal injury20.01.03.015; 12.01.05.001--Not Available
Disease progression08.01.03.0380.000347%
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