Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Lithium cation
Drug ID BADD_D01304
Description Lithium was used during the 19th century to treat gout. Lithium salts such as lithium carbonate (Li2CO3), lithium citrate, and lithium orotate are mood stabilizers. They are used in the treatment of bipolar disorder, since unlike most other mood altering drugs, they counteract both mania and depression. Lithium can also be used to augment other antidepressant drugs. It is also sometimes prescribed as a preventive treatment for migraine disease and cluster headaches. The active principle in these salts is the lithium ion Li+, which having a smaller diameter, can easily displace K+ and Na+ and even Ca+2, in spite of its greater charge, occupying their sites in several critical neuronal enzymes and neurotransmitter receptors.
Indications and Usage Lithium is used as a mood stabilizer, and is used for treatment of depression and mania. It is often used in bipolar disorder treatment.
Marketing Status Not Available
ATC Code N05AN01
DrugBank ID DB01356
KEGG ID D08133
MeSH ID D008094
PubChem ID 28486
TTD Drug ID D5MF8Y
NDC Product Code Not Available
Synonyms Lithium | Lithium-7 | Lithium 7
Chemical Information
Molecular Formula Li+
CAS Registry Number 17341-24-1
SMILES [Li+]
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Blood gas and acid base analysesCatalaseP04762Not AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Muscle twitching15.05.03.005--Not Available
Muscular weakness17.05.03.005; 15.05.06.001--
Myasthenia gravis17.05.04.001; 15.05.08.001; 10.04.05.001--
Myxoedema23.07.04.007; 05.02.03.002--Not Available
Nausea07.01.07.001--
Nephrogenic diabetes insipidus20.05.03.010; 14.05.07.002--Not Available
Nystagmus17.02.02.006; 06.05.02.006--
Oedema14.05.06.010; 08.01.07.006--Not Available
Oliguria20.01.03.004--Not Available
Optic atrophy06.09.02.001--Not Available
Optic neuritis17.04.05.001; 10.04.10.002; 06.04.08.002--Not Available
Papilloedema24.03.07.001; 17.07.02.004; 06.09.02.002--
Peripheral coldness24.04.03.006; 08.01.09.010--Not Available
Polydipsia14.05.02.001; 05.03.03.002--Not Available
Polyuria20.02.03.002--Not Available
Psoriasis23.03.14.002; 10.02.01.036--Not Available
Psychomotor retardation19.15.02.002--Not Available
Rash23.03.13.001--Not Available
Salivary gland enlargement07.06.03.002--Not Available
Salivary hypersecretion07.06.01.009--Not Available
Seizure17.12.03.001--
Sexual dysfunction21.03.02.003; 19.08.05.002--Not Available
Shock24.06.02.002--Not Available
Sinus arrhythmia02.03.03.008--Not Available
Skin ulcer24.04.03.007; 23.07.03.003--
Somnolence17.02.04.006; 19.02.05.003--
Stupor19.02.05.004; 17.02.04.007--Not Available
Swelling08.01.03.015--Not Available
Syncope24.06.02.012; 17.02.04.008; 02.01.02.008--
Thirst08.01.09.021; 14.03.02.007--Not Available
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