Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Fluphenazine
Drug ID BADD_D00935
Description A phenothiazine used in the treatment of psychoses. Its properties and uses are generally similar to those of chlorpromazine.
Indications and Usage For management of manifestations of psychotic disorders.
Marketing Status Discontinued; Prescription
ATC Code N05AB02
DrugBank ID DB00623
KEGG ID D07977
MeSH ID D005476
PubChem ID 3372
TTD Drug ID D0P5SA
NDC Product Code Not Available
Synonyms Fluphenazine | Flufenazin | Fluphenazine Hydrochloride | Hydrochloride, Fluphenazine | Lyogen | Prolixin
Chemical Information
Molecular Formula C22H26F3N3OS
CAS Registry Number 69-23-8
SMILES C1CN(CCN1CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)C(F)(F)F)CCO
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Tardive dyskinesiaD(3) dopamine receptorP35462T0255110821369; 10379516; 10893495; 9777180; 10889553
Tardive dyskinesiaD(4) dopamine receptorP21917T2498310821369; 10379516; 10893495; 9777180; 10889553
Tardive dyskinesiaD(2) dopamine receptorP14416T6716210821369; 10379516; 10893495; 9777180; 10889553
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Hyperreflexia17.02.01.002--Not Available
Hypersensitivity10.01.03.003--
Hypertension24.08.02.001--
Hypotension24.06.03.002--
Ileus paralytic07.02.05.001--Not Available
Jaundice cholestatic09.01.01.005--Not Available
Laryngeal oedema23.04.01.005; 22.04.02.001; 10.01.05.003--
Lethargy19.04.04.004; 17.02.04.003; 08.01.01.008--
Leukocytosis01.02.01.002--
Leukopenia01.02.02.001--Not Available
Libido increased21.03.02.007; 19.08.03.002--
Menstruation irregular21.01.01.005; 05.05.01.008--
Mitral valve incompetence02.07.01.002--Not Available
Muscle rigidity17.05.02.005; 15.05.04.001--Not Available
Muscle spasms15.05.03.004--
Nasal congestion22.04.04.001--
Nausea07.01.07.001--
Neurogenic bladder20.03.03.001; 17.10.01.002--Not Available
Neuroleptic malignant syndrome17.05.02.003; 15.05.04.015; 12.03.01.003; 08.05.01.005--Not Available
Oculogyric crisis17.01.03.002; 06.05.02.002--Not Available
Oedema peripheral14.05.06.011; 08.01.07.007; 02.05.04.007--
Opisthotonus17.01.03.005--Not Available
Pancytopenia01.03.03.003--Not Available
Parkinsonism17.01.05.003--Not Available
Photosensitivity reaction23.03.09.003--
Pneumonia11.01.09.003; 22.07.01.003--Not Available
Polyuria20.02.03.002--Not Available
Pruritus23.03.12.001--
Psychotic behaviour19.03.01.003--Not Available
Salivary hypersecretion07.06.01.009--Not Available
The 2th Page    First    Pre   2 3    Next   Last    Total 3 Pages