Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Flucytosine
Drug ID BADD_D00913
Description A fluorinated cytosine analog that is used as an antifungal agent.
Indications and Usage For the treatment (in combination with amphotericin B) of serious infections caused by susceptible strains of Candida (septicemia, endocarditis and urinary system infections) and/or Cryptococcus (meningitis and pulmonary infections).
Marketing Status Prescription
ATC Code D01AE21; J02AX01
DrugBank ID DB01099
KEGG ID D00323
MeSH ID D005437
PubChem ID 3366
TTD Drug ID D0S5WG
NDC Product Code 70120-095; 0187-3554; 0054-0428; 42494-339; 63629-9156; 50268-331; 63629-2148; 42794-010; 51927-4508; 60687-610; 0187-3555; 73309-270; 70120-096; 71052-466; 40032-770; 42973-193; 60687-363; 50268-332; 60687-352; 0904-6835; 43386-771; 0054-0427; 63629-2147; 59348-0016; 42794-009; 59651-331; 66639-008; 40032-771; 71666-001; 43386-770; 59651-332; 0904-6834; 63629-9157; 42494-340; 60687-599
Synonyms Flucytosine | 5-Fluorocytosine | Ancobon | Ancotil | Alcobon
Chemical Information
Molecular Formula C4H4FN3O
CAS Registry Number 2022-85-7
SMILES C1=NC(=O)NC(=C1F)N
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Bone marrow failureDihydropyrimidine dehydrogenase [NADP(+)]Q12882T758909816193; 9007910
Bone marrow failureDihydropyrimidine dehydrogenase [NADP(+)]Q12882T758909816193; 9007910; 8221682
Bone marrow failureDihydropyrimidine dehydrogenase [NADP(+)]Q12882T758909732227; 9280881; 11697844
EncephalopathyDihydropyrimidine dehydrogenase [NADP(+)]Q12882T758909732227; 9280881; 11697844
EncephalopathyDihydropyrimidine dehydrogenase [NADP(+)]Q12882T758909816193; 9007910
EncephalopathyDihydropyrimidine dehydrogenase [NADP(+)]Q12882T758909816193; 9007910; 8221682
HypertensionDihydropyrimidine dehydrogenase [NADP(+)]Q12882T758909816193; 9007910
HypertensionDihydropyrimidine dehydrogenase [NADP(+)]Q12882T758909816193; 9007910; 8221682
HypertensionDihydropyrimidine dehydrogenase [NADP(+)]Q12882T758909732227; 9280881; 11697844
NeurotoxicityDihydropyrimidine dehydrogenase [NADP(+)]Q12882T758909816193; 9007910
NeurotoxicityDihydropyrimidine dehydrogenase [NADP(+)]Q12882T758909816193; 9007910; 8221682
NeurotoxicityDihydropyrimidine dehydrogenase [NADP(+)]Q12882T758909732227; 9280881; 11697844
Toxicity to various agentsDihydropyrimidine dehydrogenase [NADP(+)]Q12882T758909816193; 9007910; 8221682
Toxicity to various agentsDihydropyrimidine dehydrogenase [NADP(+)]Q12882T758909732227; 9280881; 11697844
Toxicity to various agentsDihydropyrimidine dehydrogenase [NADP(+)]Q12882T758909816193; 9007910
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Haemoglobin13.01.05.018--Not Available
Hallucination19.10.02.002--
Headache17.14.01.001--
Hepatic function abnormal09.01.02.001--Not Available
Hepatic necrosis09.01.07.002--
Hepatitis09.01.07.004--Not Available
Hypersensitivity10.01.03.003--
Hypoglycaemia14.06.03.001; 05.06.03.001--
Hypokalaemia14.05.03.002--
Jaundice23.03.03.030; 09.01.01.004; 01.06.04.004--Not Available
Leukopenia01.02.02.001--Not Available
Nausea07.01.07.001--
Neuropathy peripheral17.09.03.003--Not Available
Pancytopenia01.03.03.003--Not Available
Paraesthesia17.02.06.005--
Parkinsonism17.01.05.003--Not Available
Photosensitivity reaction23.03.09.003--
Pruritus23.03.12.001--
Pyrexia08.05.02.003--
Rash23.03.13.001--Not Available
Renal failure20.01.03.005--Not Available
Respiratory arrest22.02.01.009--Not Available
Sedation17.02.04.005--Not Available
Seizure17.12.03.001--
Thrombocytopenia01.08.01.002--Not Available
Toxic epidermal necrolysis23.03.01.008; 12.03.01.015; 11.07.01.006; 10.01.01.006--
Urticaria23.04.02.001; 10.01.06.001--
Vertigo04.04.01.003; 17.02.12.002--
Vomiting07.01.07.003--
Cardiotoxicity12.03.01.007; 02.01.01.002--Not Available
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