Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Desloratadine
Drug ID BADD_D00615
Description Desloratadine is a second generation, tricyclic antihistamine that which has a selective and peripheral H1-antagonist action. It is the active descarboethoxy metabolite of loratidine (a second generation histamine). Desloratidine has a long-lasting effect and does not cause drowsiness because it does not readily enter the central nervous system.
Indications and Usage For the relief of symptoms of seasonal allergic rhinitis, perennial (non-seasonal) allergic rhinitis. Desloratidine is also used for the sympomatic treatment of pruritus and urticaria (hives) associated with chronic idiopathic urticaria.
Marketing Status approved; investigational
ATC Code R06AX27
DrugBank ID DB00967
KEGG ID D03693
MeSH ID C121345
PubChem ID 124087
TTD Drug ID D01GBY
NDC Product Code 53104-7613; 55111-360; 52408-0130; 66577-018; 68180-153; 62993-0805; 75895-0099; 78206-188; 65015-698; 69543-107; 71335-1000; 65691-0057; 66039-830; 50090-3975; 78206-119; 53104-7688; 62331-019; 50090-4794; 62250-619; 42291-240; 55111-551; 55111-073
UNII FVF865388R
Synonyms desloratadine | descarboethoxyloratadine | SCH 34117 | SCH-34117 | Clarinex | Neoclarityn | Aerius | descarboethoxyloratadine acetate
Chemical Information
Molecular Formula C19H19ClN2
CAS Registry Number 100643-71-8
SMILES C1CC2=C(C=CC(=C2)Cl)C(=C3CCNCC3)C4=C1C=CC=N4
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Fatigue08.01.01.002--
Feeling abnormal08.01.09.0140.001357%Not Available
Feeling hot08.01.09.009--Not Available
Gait disturbance15.03.05.013; 17.02.05.016; 08.01.02.0020.000678%
Gastrooesophageal reflux disease07.02.02.003--
Gastrointestinal disorder07.11.01.001--Not Available
Gastrointestinal pain07.01.05.005--
Generalised tonic-clonic seizure17.12.01.0020.000678%Not Available
Hallucination19.10.04.0030.001357%
Hallucination, auditory19.10.04.0040.002375%Not Available
Headache17.14.01.0010.003867%
Hepatitis09.01.07.0040.000678%Not Available
Hepatotoxicity12.03.01.008; 09.01.07.0090.001018%Not Available
Hyperbilirubinaemia14.11.01.010; 09.01.01.003; 01.06.04.0030.001357%Not Available
Hyperkinesia17.01.02.008--Not Available
Hypersensitivity10.01.03.0030.006310%
Hypertension24.08.02.0010.002035%
Hypocoagulable state01.01.02.0040.000678%Not Available
Hypotension24.06.03.002--
Increased appetite14.03.01.003; 08.01.09.027--Not Available
Infection11.01.08.002--Not Available
Infection parasitic11.01.08.003--Not Available
Insomnia19.02.01.002; 17.15.03.0020.002850%
Intentional self-injury19.12.01.002; 12.01.08.0360.001357%Not Available
Irritability19.04.02.013; 08.01.03.0110.002646%
Jaundice09.01.01.004; 23.03.03.030; 01.06.04.0040.001696%Not Available
Lacrimation increased06.08.02.004--
Lethargy19.04.04.004; 17.02.04.003; 08.01.01.0080.001018%
Lip swelling10.01.05.005; 07.05.04.005; 23.04.01.0070.001018%Not Available
Loss of consciousness17.02.04.004--Not Available
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