Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Dacarbazine
Drug ID BADD_D00568
Description An antineoplastic agent. It has significant activity against melanomas. (from Martindale, The Extra Pharmacopoeia, 31st ed, p564). Dacarbazine with Oblimersen is in clinical trials for the treatment of malignant melanoma.
Indications and Usage For the treatment of metastatic malignant melanoma. In addition, dacarbazine is also indicated for Hodgkin's disease as a secondary-line therapy when used in combination with other antineoplastic agents.
Marketing Status Prescription; Discontinued
ATC Code L01AX04
DrugBank ID DB00851
KEGG ID D00288
MeSH ID D003606
PubChem ID 2942
TTD Drug ID D0Y7ZU
NDC Product Code 54875-0003; 0143-9245; 42973-149; 0703-5075; 63323-128; 63323-127
Synonyms Dacarbazine | Dimethyl Imidazole Carboxamide | Carboxamide, Dimethyl Imidazole | Imidazole Carboxamide, Dimethyl | DTIC | ICDT | Decarbazine | 5-(3,3-Dimethyl-1-triazeno)imidazole-4-carboxamide | DIC | Dimethyl Triazeno Imidazole Carboxamide | NSC-45388 | NSC 45388 | NSC45388 | DTIC-Dome | DTIC Dome | DTICDome | Biocarbazine | Deticene
Chemical Information
Molecular Formula C6H10N6O
CAS Registry Number 4342-03-4
SMILES CN(C)N=NC1=C(NC=N1)C(=O)N
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Hepatic function abnormal09.01.02.0010.000799%Not Available
Hepatic necrosis09.01.07.002--
Hepatic vein thrombosis24.01.03.004; 09.01.06.012--Not Available
Hepatitis acute09.01.07.005--Not Available
Hepatotoxicity09.01.07.009; 12.03.01.008--Not Available
Hypersensitivity10.01.03.0030.000533%
Hypertension24.08.02.0010.000533%
Hypotension24.06.03.0020.002664%
Infection11.01.08.0020.000278%Not Available
Influenza22.07.02.001; 11.05.03.001--Not Available
Influenza like illness08.01.03.010--
Injection site pain12.07.03.011; 08.02.03.010--Not Available
Interstitial lung disease22.01.02.003; 10.02.01.0330.000208%Not Available
Lethargy19.04.04.004; 17.02.04.003; 08.01.01.008--
Leukopenia01.02.02.0010.000533%Not Available
Liver function test abnormal13.03.01.013--Not Available
Local reaction08.01.03.012--Not Available
Lung disorder22.02.07.0010.000139%Not Available
Malaise08.01.01.0030.000799%
Metastases to lung16.22.02.002; 22.08.01.0050.000139%Not Available
Metastatic malignant melanoma23.08.01.002; 16.03.01.0020.000347%Not Available
Myalgia15.05.02.001--
Nausea07.01.07.0010.001066%
Neuropathy peripheral17.09.03.0030.000799%Not Available
Neutropenia01.02.03.0040.000533%Not Available
Neutrophil count decreased13.01.06.0100.000533%
Orthostatic hypotension24.06.03.004; 17.05.01.020--Not Available
Oxygen saturation decreased13.02.01.0040.000533%Not Available
Pain08.01.08.0040.000533%
Pancytopenia01.03.03.0030.000533%Not Available
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