Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Cytarabine
Drug ID BADD_D00560
Description A pyrimidine nucleoside analog that is used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia. Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle. It also has antiviral and immunosuppressant properties. (From Martindale, The Extra Pharmacopoeia, 30th ed, p472)
Indications and Usage For the treatment of acute non-lymphocytic leukemia, acute lymphocytic leukemia and blast phase of chronic myelocytic leukemia.
Marketing Status Prescription; Discontinued
ATC Code L01BC01
DrugBank ID DB00987
KEGG ID D00168
MeSH ID D003561
PubChem ID 6253
TTD Drug ID D07XSN
NDC Product Code 67457-452; 68083-343; 58623-0026; 68083-337; 67457-455; 71288-108; 61703-303; 70516-0163; 71288-109; 61703-319; 63323-120; 71288-169; 61703-305; 71288-168; 55512-0026; 61703-304; 12848-1003
Synonyms Cytarabine | Arabinosylcytosine | Cytosine Arabinoside | Arabinoside, Cytosine | Arabinofuranosylcytosine | Aracytidine | beta-Ara C | beta Ara C | Cytarabine Hydrochloride | Cytosar | Cytosar-U | Cytosar U | Ara-C | Ara C | Aracytine | Cytonal
Chemical Information
Molecular Formula C9H13N3O5
CAS Registry Number 147-94-4
SMILES C1=CN(C(=O)N=C1N)C2C(C(C(O2)CO)O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Disorientation17.02.05.015; 19.13.01.0020.001066%Not Available
Disseminated intravascular coagulation24.01.01.010; 01.01.02.0020.001112%
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Drug hypersensitivity10.01.01.001--Not Available
Dry skin23.03.03.001--
Dysarthria19.19.03.001; 17.02.08.0010.001865%
Dysmetria17.02.02.0050.000533%Not Available
Dysphagia07.01.06.003--
Dyspnoea22.02.01.004; 02.01.03.002--
Dysuria20.02.02.0020.001332%
Ecchymosis23.06.01.001; 01.01.03.001; 24.07.06.0020.000799%Not Available
Electrocardiogram QT prolonged13.14.05.0040.002131%
Electroencephalogram abnormal13.07.03.0010.000533%Not Available
Electrolyte imbalance14.05.01.0020.001332%Not Available
Encephalopathy17.13.02.0010.000533%
Endocarditis11.01.16.001; 02.09.01.0010.000139%
Enteritis07.08.03.0020.001865%
Enterococcal bacteraemia11.02.08.0010.000799%Not Available
Enterocolitis07.08.03.0030.000556%
Ephelides23.05.01.005--Not Available
Epilepsy17.12.03.0020.000799%Not Available
Epistaxis24.07.01.005; 22.04.03.0010.001598%
Epstein-Barr virus infection11.05.10.0040.001598%
Erythema23.03.06.0010.002131%Not Available
Escherichia sepsis11.02.10.0020.001598%Not Available
Eye irritation06.04.05.0030.000533%Not Available
Fatigue08.01.01.002--
Febrile neutropenia08.05.02.004; 01.02.03.0020.043425%
Fluid overload02.05.04.004; 14.05.06.0010.005328%Not Available
Flushing24.03.01.002; 23.06.05.003; 08.01.03.025--
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