Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Clomiphene citrate
Drug ID BADD_D00498
Description A triphenyl ethylene stilbene derivative which is an estrogen agonist or antagonist depending on the target tissue.
Indications and Usage Used mainly in female infertility due to anovulation (e.g. due to polycystic ovary syndrome) to induce ovulation.
Marketing Status Prescription; Discontinued
ATC Code G03GB02
DrugBank ID DB00882
KEGG ID D00962
MeSH ID D002996
PubChem ID 60974
TTD Drug ID D0I5WB
NDC Product Code 63275-9964; 49884-701; 73309-046; 17369-817; 50090-0678; 63629-2165; 63629-5302; 68071-4676; 38779-0390; 62991-3139; 51927-0183; 73309-017; 43647-456; 61919-375; 10577-916; 51927-0056; 46014-1122; 62991-2702; 51552-1580; 48087-0025; 71052-338; 49169-1040; 68071-2638; 73309-047; 68981-028; 48087-0144
Synonyms Clomiphene | Clomifene | Chloramiphene | Clomifen | Clomiphene Citrate | Citrate, Clomiphene | Clomiphene Hydrochloride | Hydrochloride, Clomiphene | Serophene | Gravosan | Klostilbegit | Clostilbegit | Clomid | Clomide | Dyneric
Chemical Information
Molecular Formula C32H36ClNO8
CAS Registry Number 50-41-9
SMILES CCN(CC)CCOC1=CC=C(C=C1)C(=C(C2=CC=CC=C2)Cl)C3=CC=CC=C3.C(C(=O)O)C(CC(=O)O)(C(=O) O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Dermatitis23.03.04.002--Not Available
Diaphragmatic hernia22.09.02.001; 07.16.01.002--Not Available
Diarrhoea07.02.01.001--
Diplopia17.17.01.005; 06.02.06.002--Not Available
Dizziness02.01.02.004; 24.06.02.007; 17.02.05.003--
Dwarfism15.02.03.005; 05.03.02.002--Not Available
Dysfunctional uterine bleeding21.01.01.001; 05.05.01.003--Not Available
Dyspnoea22.02.01.004; 02.01.03.002--
Ear malformation04.06.02.001; 03.13.02.001--Not Available
Ectopic pregnancy18.02.02.002--Not Available
Endometrial cancer21.07.02.002; 16.12.02.001--Not Available
Endometriosis21.07.01.004--Not Available
Erythema23.03.06.001--Not Available
Erythema multiforme23.03.01.003; 10.01.03.015--
Erythema nodosum10.02.01.020; 23.07.02.001--Not Available
Exomphalos07.16.03.002; 03.04.07.001--Not Available
Eye pain06.08.03.002--
Fallot's tetralogy03.07.06.001; 02.08.01.002--Not Available
Fatigue08.01.01.002--
Fibrocystic breast disease16.14.01.003; 21.05.01.002--Not Available
Glioblastoma multiforme17.20.02.001; 16.30.02.001--Not Available
Hair texture abnormal23.02.06.004--
Headache17.14.01.001--
Hepatic adenoma16.06.01.002; 09.04.01.002--Not Available
Hepatitis09.01.07.004--Not Available
Hodgkin's disease16.31.01.001; 01.16.01.001--Not Available
Hydrocephalus17.07.01.001--
Hypersensitivity10.01.03.003--
Hypertension24.08.02.001--
Hypertrichosis23.02.04.002--
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