Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Clobetasol propionate
Drug ID BADD_D00490
Description Clobetasol propionate is a prednisolone derivative with higher specificity for glucocorticoid receptors than mineralocorticoid receptors.[L11815] It has demonstrated superior activity compared to [fluocinonide][A190963] and was first described in the literature in 1974.[A190936] Clobetasol Propionate was granted FDA approval on 27 December 1985.[L11809]
Indications and Usage For short-term topical treatment of the inflammatory and pruritic manifestations of moderate to severe corticosteroid-responsive dermatoses of the scalp.
Marketing Status Prescription; Discontinued
ATC Code D07AD01
DrugBank ID DB01013
KEGG ID D01272
MeSH ID D002990
PubChem ID 32798
TTD Drug ID D0H0YD
NDC Product Code 63629-8637; 63739-064; 43538-950; 71589-004; 0168-0301; 50742-304; 43538-951; 50383-269; 63629-8639; 50383-267; 68071-1599; 0378-8055; 71589-002; 63629-2395; 50383-978; 49452-2141; 51672-1258; 71589-003; 63629-2393; 50383-270; 50090-4146; 0781-7137; 70700-106; 70518-2068; 71085-007; 46439-8747; 45802-637; 45802-961; 72189-262; 0299-3848; 0378-8147; 62559-980; 40032-028; 0472-0400; 16714-992; 70752-153; 62332-547; 68071-4706; 76003-0325; 71589-007; 51672-1347; 52565-051; 0168-0163; 50090-2289; 43386-096; 51672-4193; 0299-3847; 0378-8167; 33342-321; 52128-158; 70710-1401; 51672-1371; 63629-2330; 0299-3849; 0472-0404; 68462-625; 59088-762; 68788-7768; 52565-082; 70700-109; 70771-1498; 68788-7212; 68040-713; 10337-163; 69238-1732; 42291-076; 63629-2332; 0168-0269; 40032-096; 0472-0403; 63629-2392; 68462-532; 51672-1293; 71428-005; 62991-1492; 63629-2331; 71205-151; 50090-5778; 51672-1297; 70771-1209; 66993-939; 51672-1350; 52565-094; 68180-956; 68462-530; 64958-0101; 62332-425; 0168-0293; 69238-1532; 45802-437; 68462-608; 22552-0006; 79572-008; 16714-730; 62332-486; 13668-603; 50383-266; 70518-1178; 50090-5264; 70771-1080; 0713-0656; 51927-2627; 60429-901; 45802-925; 50090-5488; 51672-1294; 49502-537; 60432-133; 62332-465; 0168-0162; 50090-4630; 70710-1456; 50090-3820; 72578-085; 13668-569; 43538-953; 16714-030; 43538-952; 68462-529; 51552-0605; 68180-536; 63629-2329; 10337-162; 42571-362; 69482-700; 50383-268; 42291-077; 0378-8182; 64980-441; 50090-4647; 50090-5079; 68462-480; 52565-055; 50090-2405; 68180-551; 0472-0402; 51672-1259; 0591-4039; 63646-500; 63629-8638; 16714-782; 50383-979; 63629-2394; 52565-039; 60429-902; 46439-8708; 68382-998; 43386-028; 68071-1600; 68788-7581; 62332-548; 70771-1442; 71589-006; 50090-0548
Synonyms Clobetasol | Clofenazon | Clobetasol Propionate | Clobetasol 17-Propionate | Clobetasol 17 Propionate | Clobex | Cormax | OLUX | Dermovate | Embeline | Embeline E | Temovate
Chemical Information
Molecular Formula C25H32ClFO5
CAS Registry Number 25122-46-7
SMILES CCC(=O)OC1(C(CC2C1(CC(C3(C2CCC4=CC(=O)C=CC43C)F)O)C)C)C(=O)CCl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Gait disturbance08.01.02.002; 17.02.05.0160.000266%
Glaucoma06.03.01.0020.000266%
Glucocorticoids increased13.10.09.003--Not Available
Glycosuria20.02.01.005--
Headache17.14.01.001--
Hepatic steatosis14.08.04.005; 09.01.07.0030.000139%Not Available
Hyperadrenocorticism24.08.02.005; 14.11.01.009; 05.01.01.003--Not Available
Hyperglycaemia05.06.02.002; 14.06.02.002--
Hypersensitivity10.01.03.0030.000266%
Hypertension24.08.02.0010.000664%
Hypertrichosis23.02.04.002--
Hypoaesthesia17.02.06.023--Not Available
Infection11.01.08.002--Not Available
Insomnia19.02.01.002; 17.15.03.0020.000266%
Instillation site pain12.07.01.008; 08.02.01.008--Not Available
Kaposi's sarcoma11.05.17.001; 16.33.02.0010.000532%Not Available
Lethargy19.04.04.004; 17.02.04.003; 08.01.01.0080.000399%
Leukoderma23.05.02.001--Not Available
Miliaria23.02.03.014--Not Available
Necrotising fasciitis15.03.03.004; 11.01.17.0020.000104%Not Available
Oedema peripheral14.05.06.011; 08.01.07.007; 02.05.04.007--
Osteonecrosis24.04.05.004; 15.02.04.0070.000069%
Pain08.01.08.004--
Pain in extremity15.03.04.0100.000399%
Paraesthesia17.02.06.0050.000266%
Pruritus23.03.12.0010.001462%
Psoriasis23.03.14.002; 10.02.01.0360.000532%Not Available
Purpura24.07.06.005; 01.01.04.003; 23.06.01.004--
Pyoderma23.09.01.007; 11.01.12.009--Not Available
Pyrexia08.05.02.0030.000532%
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