Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Cefixime
Drug ID BADD_D00388
Description Cefixime, an antibiotic, is a third-generation cephalosporin like ceftriaxone and cefotaxime. Cefixime is highly stable in the presence of beta-lactamase enzymes. As a result, many organisms resistant to penicillins and some cephalosporins due to the presence of beta-lactamases, may be susceptible to cefixime. The antibacterial effect of cefixime results from inhibition of mucopeptide synthesis in the bacterial cell wall.
Indications and Usage For use in the treatment of the following infections when caused by susceptible strains of the designated microorganisms: (1) uncomplicated urinary tract infections caused by Escherichia coli and Proteus mirabilis, (2) otitis media caused by Haemophilus influenzae (beta-lactamase positive and negative strains), Moraxella catarrhalis (most of which are beta-lactamase positive), and S. pyogenes, (3) pharyngitis and tonsillitis caused by S. pyogenes, (4) acute bronchitis and acute exacerbations of chronic bronchitis caused by Streptococcus pneumoniae and Haemophilus influenzae (beta-lactamase positive and negative strains), and (5) uncomplicated gonorrhea (cervical/urethral) caused by Neisseria gonorrhoeae (penicillinase- and non-penicillinase-producing strains).
Marketing Status Prescription; Discontinued
ATC Code J01DD08
DrugBank ID DB00671
KEGG ID D00258
MeSH ID D020682
PubChem ID 5362065
TTD Drug ID D06OVY
NDC Product Code 68180-405; 54348-797; 68180-407; 70518-3221; 67877-584; 16714-767; 61788-3000; 62250-663; 65862-751; 43598-673; 62250-668; 65862-752; 27437-208; 65862-791; 27437-201; 62250-664; 16714-766; 27437-207; 27437-206; 68180-202; 43598-674; 68180-423; 27437-203; 70518-2749; 27437-205
Synonyms Cefixime | Suprax | Cefixime Anhydrous | Cefixime Trihydrate | FK-027 | FK027 | FK 027 | FR-17027 | FR 17027 | FR17027
Chemical Information
Molecular Formula C16H15N5O7S2
CAS Registry Number 79350-37-1
SMILES C=CC1=C(N2C(C(C2=O)NC(=O)C(=NOCC(=O)O)C3=CSC(=N3)N)SC1)C(=O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Pneumonia pneumococcal22.07.06.010; 11.02.06.0090.003316%Not Available
Pneumonia streptococcal11.02.06.005; 22.07.06.006--Not Available
Prothrombin time prolonged13.01.02.012--Not Available
Pruritus23.03.12.0010.004974%
Pruritus genital23.03.12.008; 21.10.01.002--Not Available
Pseudomembranous colitis07.19.01.003; 11.02.02.002--Not Available
Pulmonary embolism24.01.06.001; 22.06.02.0010.003316%Not Available
Pyrexia08.05.02.0030.016581%
Rash23.03.13.0010.004974%Not Available
Rash maculo-papular23.03.13.0040.003316%
Renal failure20.01.03.005--Not Available
Seizure17.12.03.001--
Serum sickness12.02.08.004; 10.01.03.0040.003316%
Serum sickness-like reaction08.01.03.003; 10.01.03.0050.003316%Not Available
Shock24.06.02.002--Not Available
Sluggishness08.01.01.0040.004974%Not Available
Stevens-Johnson syndrome23.03.01.007; 12.03.01.014; 11.07.01.005; 10.01.03.0200.003316%
Superinfection11.01.08.009--Not Available
Tachycardia02.03.02.0070.004974%Not Available
Thrombocytopenia01.08.01.002--Not Available
Thrombocytosis01.08.02.001--Not Available
Toxic epidermal necrolysis23.03.01.008; 12.03.01.015; 11.07.01.006; 10.01.01.006--
Urinary tract infection20.08.02.001; 11.01.14.004--
Urticaria10.01.06.001; 23.04.02.0010.006632%
Vaginal infection11.01.10.002; 21.14.02.002--
Vaginal inflammation21.14.02.001--
Vomiting07.01.07.0030.009948%
Tubulointerstitial nephritis20.05.02.0020.004974%Not Available
Haemorrhage24.07.01.0020.003316%Not Available
Toxic skin eruption23.03.05.003; 10.01.01.0080.004974%Not Available
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