Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Tourette's disorder
ADR ID BADD_A04356
ADR Hierarchy
03      Congenital, familial and genetic disorders
03.10      Neurological disorders congenital
03.10.01      Neurological disorders congenital NEC
03.10.01.001      Tourette's disorder
17      Nervous system disorders
17.19      Congenital and peripartum neurological conditions
17.19.02      Congenital and hereditary neurological disorders NEC
17.19.02.001      Tourette's disorder
19      Psychiatric disorders
19.11      Changes in physical activity
19.11.04      Tic disorders
19.11.04.002      Tourette's disorder
Description A neuropsychological disorder related to alterations in DOPAMINE metabolism and neurotransmission involving frontal-subcortical neuronal circuits. Both multiple motor and one or more vocal tics need to be present with TICS occurring many times a day, nearly daily, over a period of more than one year. The onset is before age 18 and the disturbance is not due to direct physiological effects of a substance or a another medical condition. The disturbance causes marked distress or significant impairment in social, occupational, or other important areas of functioning. (From DSM-IV, 1994; Neurol Clin 1997 May;15(2):357-79) [MeSH]
MedDRA Code 10044126
MeSH ID D005879; D005879; D005879
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Brissaud's II | Coprolalia-generalized tic | Gilles de la Tourette | Gilles de la Tourette syndrome | Gilles de la Tourette's | Gilles de la Tourette's disorder | Guinon's myospasia impulsiva | Syndrome Gilles de la Tourette | Syndrome Tourette | Tourette syndrome | Tourette's disorder | Tourette's syndrome | Tourettes syndrome | Tourette's syndrome aggravated | Tourette Syndrome | Syndrome, Tourette | Combined Vocal and Multiple Motor Tic Disorder | Gilles de la Tourette Syndrome | Gilles de la Tourette's Disease | Multiple Motor and Vocal Tic Disorder, Combined | Gilles De La Tourette's Syndrome | Tourette Disease | Tourette Disorder | Tourette's Disease | Tourettes Disease | Tourette's Disorder | Tourettes Disorder | Tourette's Syndrome | Tourettes Syndrome | Chronic Motor and Vocal Tic Disorder | Combined Multiple Motor and Vocal Tic Disorder | Tic Disorder, Combined Vocal and Multiple Motor
ADR Related Proteins
Protein Name UniProt AC TTD Target ID
Not AvailableNot AvailableNot Available
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00130Amphetamine--
BADD_D00131Amphetamine sulfate--
BADD_D00475Citalopram0.000333%
BADD_D00631Dexmethylphenidate hydrochloride--
BADD_D00636Dextroamphetamine--
BADD_D00637Dextroamphetamine sulfate--
BADD_D00932Fluoxetine0.000182%
BADD_D01046Guanfacine0.000699%
BADD_D01299Lisdexamfetamine dimesylate--
BADD_D01407Methamphetamine--
BADD_D01431Methylphenidate0.000459%
BADD_D01432Methylphenidate hydrochloride--
BADD_D01496Montelukast0.000139%
BADD_D01705Pemoline--
BADD_D02016Sibutramine--
BADD_D02017Sibutramine hydrochloride--
BADD_D02175Tetrabenazine0.003921%
BADD_D02329Valproic acid0.000443%
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