Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Insulin resistance
ADR ID BADD_A02367
ADR Hierarchy
05      Endocrine disorders
05.06      Glucose metabolism disorders (incl diabetes mellitus)
05.06.02      Hyperglycaemic conditions NEC
05.06.02.003      Insulin resistance
14      Metabolism and nutrition disorders
14.06      Glucose metabolism disorders (incl diabetes mellitus)
14.06.02      Hyperglycaemic conditions NEC
14.06.02.003      Insulin resistance
Description Diminished effectiveness of INSULIN in lowering blood sugar levels: requiring the use of 200 units or more of insulin per day to prevent HYPERGLYCEMIA or KETOSIS. [MeSH]
MedDRA Code 10022489
MeSH ID D007333
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Insulin resistance | Insulin Resistance | Resistance, Insulin | Insulin Sensitivity | Sensitivity, Insulin
ADR Related Proteins
Protein Name UniProt AC TTD Target ID
AdiponectinQ15848T15572
AP-2 complex subunit alpha-2O94973Not Available
AP-2 complex subunit betaP63010Not Available
Cellular retinoic acid-binding protein 1P29762Not Available
Cytochrome P450 3A43Q9HB55Not Available
Lipoprotein lipaseP06858T28692
Retinoic acid receptor RXR-alphaP19793T13726
Solute carrier family 2, facilitated glucose transporter member 1P17809Not Available
Solute carrier family 2, facilitated glucose transporter member 4P14142Not Available
Transcription factor AP-2-alphaP05549T71317
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00008Abacavir--
BADD_D00136Amprenavir--
BADD_D00165Aripiprazole--
BADD_D00176Atazanavir--
BADD_D00511Clozapine--
BADD_D00586Darunavir--
BADD_D00623Dexamethasone--
BADD_D00749Efavirenz--
BADD_D00766Emtricitabine--
BADD_D00932Fluoxetine--
BADD_D00961Fosamprenavir calcium--
BADD_D01030Glyburide--
BADD_D01150Indinavir--
BADD_D01242Lamivudine--
BADD_D01401Metformin--
BADD_D01418Methotrexate--
BADD_D01550Nelfinavir mesylate--
BADD_D01557Nevirapine--
BADD_D01599Olanzapine--
BADD_D01888Quetiapine--
BADD_D01951Risperidone--
BADD_D01989Saquinavir mesylate--
BADD_D02026Simvastatin--
BADD_D02068Stavudine--
BADD_D02155Tenofovir disoproxil--
BADD_D02227Tipranavir disodium--
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