Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Emtricitabine
Drug ID BADD_D00766
Description Emtricitabine is a nucleoside reverse transcriptase inhibitor (NRTI) indicated for the treatment of HIV infection in adults[L9019] or combined with [tenofovir alafenamide] for the prevention of HIV-1 infection in high risk adolescents and adults.[L9010] Emtricitabine is a cytidine analogue.[L9019] The drug works by inhibiting HIV reverse transcriptase, preventing transcription of HIV RNA to DNA.[L9019] Emtricitabine was granted FDA approval on 2 July 2003.[L9019]
Indications and Usage Indicated, in combination with other antiretroviral agents, for the treatment of HIV-1 infection in adults and for postexposure prophylaxis of HIV infection in health care workers and others exposed occupationally or nonoccupationally via percutaneous injury or mucous membrane or nonintact skin contact with blood, tissues, or other body fluids associated with risk for transmission of the virus.
Marketing Status Prescription
ATC Code J05AF09
DrugBank ID DB00879
KEGG ID D01199
MeSH ID D000068679
PubChem ID 60877
TTD Drug ID D0S9SD
NDC Product Code 68554-0064; 70518-1847; 59997-0005; 42385-304; 72761-008; 69097-642; 52696-0008; 65862-305; 70518-2906; 42385-710; 49711-1516; 61958-0601; 69037-0003; 66721-400; 65015-838; 33342-500; 53104-7637; 68554-0027; 70966-0024; 65015-827; 61958-0602; 65015-883; 66406-0209
Synonyms Emtricitabine | Beta-L-2',3'-dideoxy-5-fluoro-3'-thiacytidine | Beta L 2',3' dideoxy 5 fluoro 3' thiacytidine | Coviracil | Emtriva
Chemical Information
Molecular Formula C8H10FN3O3S
CAS Registry Number 143491-57-0
SMILES C1C(OC(S1)CO)N2C=C(C(=NC2=O)N)F
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Abnormal dreams19.02.03.001; 17.15.02.001--Not Available
Abortion spontaneous18.01.04.0010.017109%Not Available
Alanine aminotransferase increased13.03.01.003--
Amylase13.05.01.010--Not Available
Amylase increased13.05.01.009--
Anaemia01.03.02.001--
Angioedema23.04.01.001; 10.01.05.009--Not Available
Anxiety19.06.02.002--
Arthralgia15.01.02.001--
Aspartate aminotransferase increased13.03.01.006--
Asthenia08.01.01.001--Not Available
Autoimmune hepatitis10.04.09.001; 09.01.07.0190.012832%Not Available
Back pain15.03.04.005--
Basedow's disease10.04.08.004; 06.09.04.003; 05.02.02.003--Not Available
Blood bilirubin increased13.03.01.008--
Blood cholesterol13.12.01.014--Not Available
Blood creatine phosphokinase13.04.01.009--Not Available
Blood creatine phosphokinase increased13.04.01.001--
Blood creatinine increased13.13.01.004--
Blood glucose13.02.02.009--Not Available
Blood glucose decreased13.02.02.001--Not Available
Blood triglycerides13.12.03.004--Not Available
Blood triglycerides increased13.12.03.001--Not Available
Body temperature increased13.15.01.001--Not Available
Bone pain15.02.01.001--
Breast enlargement21.05.04.001--Not Available
Cardiac arrest02.03.04.0010.002232%
Confusional state19.13.01.001; 17.02.03.0050.005579%
Cough22.02.03.001--
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