Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Quetiapine
Drug ID BADD_D01888
Description Initially approved by the FDA in 1997, quetiapine is a second-generation atypical antipsychotic used in schizophrenia, major depression, and bipolar disorder.[L8546] Quetiapine demonstrates a high level of therapeutic efficacy and low risk of adverse effects during long-term treatment. It is well-tolerated and a suitable option for some patients with high sensitivity to other drugs, such as [Clozapine] and [Olanzapine].[A2189]
Indications and Usage For the treatment of schizophrenia and related psychotic disorders.
Marketing Status Prescription; Discontinued
ATC Code N05AH04
DrugBank ID DB01224
KEGG ID D08456
MeSH ID D000069348
PubChem ID 5002
TTD Drug ID D0H7KF
NDC Product Code 0615-7987; 50090-2307; 65862-877; 63629-4939; 16714-456; 65862-876; 0310-0275; 71610-538; 0093-8166; 70518-0239; 0093-8164; 71093-139; 65862-874; 33342-136; 63629-2482; 71205-402; 63629-2480; 50228-383; 16729-146; 71335-0432; 63629-2481; 68001-181; 63629-7116; 68001-183; 50090-2831; 50090-2338; 71205-026; 0615-7988; 80425-0107; 0615-8118; 70518-0570; 71205-401; 70518-0752; 16714-457; 50090-2689; 68001-180; 70518-0229; 16729-147; 50090-3749; 16729-148; 0310-0274; 50228-381; 70518-0432; 68788-7412; 50090-5451; 50090-2830; 16729-150; 65862-873; 71093-135; 71093-137; 53002-1529; 68001-182; 0310-0282; 0615-7986; 16714-454; 71093-138; 71093-136; 80425-0143; 68788-7185; 70518-0289; 68788-7186; 0310-0279; 16714-455; 16714-452; 50228-382; 33342-135; 68001-185; 50228-380; 60687-371; 16729-149; 68788-7590; 53002-1516; 65862-875; 33342-134; 0310-0278; 0310-0281; 63629-2478; 60687-338; 50090-4788; 68788-7184; 0093-8162; 0310-0284; 68001-184; 16729-145; 63629-2479; 0615-8119; 16714-453; 33342-137; 70518-2828; 0093-8163; 0310-0283; 68071-4161; 60687-327; 0093-8165; 60687-360; 50228-384; 60687-349; 0093-2063; 60687-382; 0310-0271; 0310-0272; 0310-0280
Synonyms Quetiapine Fumarate | Ethanol, 2-(2-(4-dibenzo(b,f)(1,4)thiazepin-11-yl-1-piperazinyl)ethoxy)-, (E)-2-butenedioate (2:1) (salt) | Seroquel | ICI 204,636 | ICI-204636 | ICI204636 | ICI 204636 | Quetiapine | 2-(2-(4-dibenzo(b,f)(1,4)thiazepine-11-yl-1-piperazinyl)ethoxy)ethanol
Chemical Information
Molecular Formula C21H25N3O2S
CAS Registry Number 111974-69-7
SMILES C1CN(CCN1CCOCCO)C2=NC3=CC=CC=C3SC4=CC=CC=C42
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001--Not Available
Abdominal distension07.01.04.001--
Abdominal pain07.01.05.002--
Abdominal pain upper07.01.05.003--
Abdominal tenderness07.01.05.0040.000100%Not Available
Abnormal dreams19.02.03.001; 17.15.02.0010.001910%Not Available
Abnormal weight gain14.03.02.0100.002165%Not Available
Abortion missed18.01.01.0020.000764%Not Available
Abortion spontaneous18.01.04.001--Not Available
Accelerated hypertension24.08.01.0030.000255%Not Available
Accidental overdose12.06.03.002--Not Available
Accommodation disorder06.02.04.001--Not Available
Acidosis14.01.03.0020.001401%
Acne23.02.01.001--Not Available
Acoustic stimulation tests abnormal13.07.01.0040.000233%Not Available
Activated partial thromboplastin time prolonged13.01.02.001--
Acute abdomen07.01.06.0150.000382%Not Available
Acute hepatic failure09.01.03.0010.000365%Not Available
Acute myeloid leukaemia16.01.05.001; 01.10.05.001--Not Available
Acute psychosis19.03.01.0010.000255%Not Available
Acute respiratory distress syndrome22.01.03.0010.000698%
Acute respiratory failure22.02.06.001; 14.01.04.0040.000892%Not Available
Adrenal insufficiency14.11.01.004; 05.01.02.0010.000509%
Affective disorder19.04.04.0010.000637%Not Available
Aggression19.05.01.0010.008661%Not Available
Agitation19.06.02.001; 17.02.05.0120.018341%
Agitation neonatal19.06.02.007; 17.02.05.028; 18.04.04.0020.001274%Not Available
Agranulocytosis01.02.03.001--Not Available
Akathisia19.06.02.006; 17.01.02.0020.005604%
Akinesia17.01.02.0030.000382%Not Available
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