Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Constipation
ADR ID BADD_A01059
ADR Hierarchy
07      Gastrointestinal disorders
07.02      Gastrointestinal motility and defaecation conditions
07.02.02      Gastrointestinal atonic and hypomotility disorders NEC
07.02.02.001      Constipation
Description A disorder characterized by irregular and infrequent or difficult evacuation of the bowels. [CTCAE] Infrequent or difficult evacuation of FECES. These symptoms are associated with a variety of causes, including low DIETARY FIBER intake, emotional or nervous disturbances, systemic and structural disorders, drug-induced aggravation, and infections. | Difficult defecation. | Symptom characterized by the passage of stool once a week or less. [MeSH]
MedDRA Code 10010774
MeSH ID D003248
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE)
Synonym
Constipation | Constipation (excl faecal impaction) | Iatrogenic constipation | Obstipation | Constipation aggravated | Constipation (excl fecal impaction) | Stools absent | Constipation chronic | Opioid induced constipation | Slow transit constipation | Chronic idiopathic constipation | Absent bowel movement | Habitual constipation | Dyschezia | Colonic Inertia
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D01578Nitrofurantoin (monohydrate/macrocrystals)--
BADD_D01581Nivolumab--
BADD_D01582Nizatidine--
BADD_D01587Norfloxacin--
BADD_D01588Nortriptyline0.000261%
BADD_D01589Nortriptyline hydrochloride--
BADD_D01590Nuvaring--
BADD_D01592Obeticholic acid0.095699%
BADD_D01595Octreotide acetate--
BADD_D01598Ofloxacin--
BADD_D01599Olanzapine--
BADD_D01600Olanzapine pamoate--
BADD_D01601Olaparib--
BADD_D01602Olmesartan0.010761%
BADD_D01604Olodaterol--
BADD_D01609Omacetaxine mepesuccinate--
BADD_D01611Omega-3-acid ethyl esters--
BADD_D01612Omega-3-carboxylic acids--
BADD_D01613Omega-3-fatty acids--
BADD_D01614Omeprazole0.000010%
BADD_D01615Omeprazole magnesium--
BADD_D01616Onabotulinumtoxina--
BADD_D01617Ondansetron0.000255%
BADD_D01618Ondansetron hydrochloride--
BADD_D01619Opium tincture--
BADD_D01620Oprelvekin--
BADD_D01621Optimark--
BADD_D01624Orlistat0.084264%
BADD_D01625Orphenadrine--
BADD_D01626Orphenadrine citrate--
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