Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Orphenadrine citrate
Drug ID BADD_D01626
Description A muscarinic antagonist used to treat drug-induced parkinsonism and to relieve pain from muscle spasm.
Indications and Usage Indicated for the treatment of Parkinson's disease.
Marketing Status Prescription; Discontinued
ATC Code M03BC01
DrugBank ID DB01173
KEGG ID D00774
MeSH ID D009966
PubChem ID 83823
TTD Drug ID D0D9FV
NDC Product Code 49452-4936; 51927-0006; 63275-9918; 22568-1022; 61919-177; 51552-1353; 63187-122; 43063-407; 63187-632; 61919-507; 0641-6182; 17478-538; 71335-0117; 80425-0117; 68788-9138; 67763-119; 50090-0169; 66267-158; 49999-046; 43386-480; 51927-0127; 50090-2438; 50090-3150; 46016-0140; 0591-3222; 63629-1564; 0115-2011; 67296-0709; 71554-012; 38779-0452; 53002-5430; 60760-810; 0185-0022
Synonyms Orphenadrine | Methyldiphenylhydramine | Lysantin | Mefenamine | Mephenamine | Norflex | Orphenadrine Citrate | Citrate, Orphenadrine | Orphenadrine Hydrochloride | Hydrochloride, Orphenadrine | Sodium Mefenamine | Mefenamine, Sodium | Disipal | Norflex Orphenadrine Citrate | Citrate, Norflex Orphenadrine | Orphenadrine Citrate, Norflex
Chemical Information
Molecular Formula C24H31NO8
CAS Registry Number 4682-36-4
SMILES CC1=CC=CC=C1C(C2=CC=CC=C2)OCCN(C)C.C(C(=O)O)C(CC(=O)O)(C(=O)O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Agitation19.06.02.001; 17.02.05.012--
Anaphylactic reaction24.06.03.006; 10.01.07.001--
Asthenia08.01.01.001--Not Available
Constipation07.02.02.001--
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Dry skin23.03.03.001--
Hallucination19.10.02.002--
Headache17.14.01.001--
Hypersensitivity10.01.03.003--
Intraocular pressure increased13.07.04.002--Not Available
Mydriasis17.02.11.003; 06.05.03.004--Not Available
Nausea07.01.07.001--
Palpitations02.01.02.003--
Pruritus23.03.12.001--
Somnolence19.02.05.003; 17.02.04.006--
Tachycardia02.03.02.007--Not Available
Tremor17.01.06.002--
Urinary hesitation20.02.02.009--Not Available
Urinary retention20.02.02.011--
Urticaria23.04.02.001; 10.01.06.001--
Vision blurred17.17.01.010; 06.02.06.007--
Vomiting07.01.07.003--
Epigastric discomfort07.01.02.004--Not Available
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