Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Nortriptyline hydrochloride
Drug ID BADD_D01589
Description Nortriptyline hydrochloride, the active metabolite of [amitriptyline], is a tricyclic antidepressant (TCA).[L11878] It is used in the treatment of major depression and is also used off-label for chronic pain and other conditions.[L11881]
Indications and Usage Primarily indicated for the relief of symptoms of depression.
Marketing Status Prescription; Discontinued
ATC Code N06AA10
DrugBank ID DB00540
KEGG ID D00816
MeSH ID D009661
PubChem ID 441358
TTD Drug ID D04WFD
NDC Product Code 51672-4004; 60760-401; 51672-4001; 70771-1612; 70710-1156; 71335-0155; 50090-0507; 67544-078; 60760-508; 43063-897; 50090-1323; 63187-809; 0591-5787; 71335-1726; 55700-501; 68071-3232; 51927-0128; 49452-4858; 17337-0534; 0406-9912; 43063-722; 46438-0049; 0121-0678; 70518-1522; 68788-7216; 55700-668; 0406-9913; 68071-3211; 63187-759; 70518-1187; 62991-2905; 70710-1155; 0591-5789; 70518-0708; 63187-153; 50090-0537; 51862-948; 61919-510; 71335-1773; 51927-2175; 0093-0810; 61919-353; 70771-1613; 68071-3109; 72189-177; 66577-025; 71205-254; 58118-4002; 71335-1552; 51862-946; 0093-0812; 68788-8158; 0406-9910; 71335-0065; 71554-011; 63187-396; 51862-947; 60760-811; 0093-0813; 70771-1615; 70710-1153; 50268-605; 51862-945; 70518-0702; 60687-293; 70518-0741; 0591-5786; 54154-007; 51862-016; 0591-5788; 71335-0426; 50268-604; 51672-4002; 68071-2327; 60687-265; 51672-4003; 61919-590; 70710-1154; 50268-603; 0406-9911; 63187-227; 63187-798; 71335-1743; 60687-281; 63187-088; 63187-715; 70771-1614; 64330-018; 68788-9830; 71335-0083; 63629-3204; 0093-0811
Synonyms Nortriptyline | Desitriptyline | Desmethylamitriptylin | Allegron | Apo-Nortriptyline | Apo Nortriptyline | Aventyl | Gen-Nortriptyline | Gen Nortriptyline | Paxtibi | Nortrilen | Nortriptyline Hydrochloride | Hydrochloride, Nortriptyline | Novo-Nortriptyline | Novo Nortriptyline | Nu-Nortriptyline | Nu Nortriptyline | Pamelor | PMS-Nortriptyline | PMS Nortriptyline | ratio-Nortriptyline | ratio Nortriptyline | Norfenazin
Chemical Information
Molecular Formula C19H22ClN
CAS Registry Number 894-71-3
SMILES CNCCC=C1C2=CC=CC=C2CCC3=CC=CC=C31.Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Poisoning and toxicityCytochrome P450 2D6P10635T57392Not Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Accommodation disorder06.02.04.001--Not Available
Agitation17.02.05.012; 19.06.02.001--
Agranulocytosis01.02.03.001--Not Available
Alopecia23.02.02.001--
Anxiety19.06.02.002--
Arrhythmia02.03.02.001--Not Available
Asthenia08.01.01.001--Not Available
Ataxia17.02.02.001; 08.01.02.004--
Atrioventricular block02.03.01.002--Not Available
Blood glucose decreased13.02.02.001--Not Available
Blood glucose increased13.02.02.002--Not Available
Breast enlargement21.05.04.001--Not Available
Cerebrovascular accident24.03.05.001; 17.08.01.007--
Confusional state19.13.01.001; 17.02.03.005--
Constipation07.02.02.001--
Coordination abnormal17.02.02.004--Not Available
Delusion19.10.01.001--
Diarrhoea07.02.01.001--
Disorientation19.13.01.002; 17.02.05.015--Not Available
Dizziness17.02.05.003; 02.01.02.004; 24.06.02.007--
Dry mouth07.06.01.002--
Dysgeusia17.02.07.003; 07.14.03.001--
Dyspepsia07.01.02.001--
Electroencephalogram abnormal13.07.03.001--Not Available
Eosinophilia01.02.04.001--
Extrapyramidal disorder17.01.02.007--
Face oedema08.01.07.003; 23.04.01.004; 10.01.05.002--
Fatigue08.01.01.002--
Flushing24.03.01.002; 23.06.05.003; 08.01.03.025--
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