Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Nortriptyline
Drug ID BADD_D01588
Description Nortriptyline hydrochloride, the active metabolite of [amitriptyline], is a tricyclic antidepressant (TCA).[L11878] It is used in the treatment of major depression and is also used off-label for chronic pain and other conditions.[L11881]
Indications and Usage Nortriptyline is indicated for the relief of the symptoms of major depressive disorder (MDD).[L11878] Some off-label uses for this drug include treatment of chronic pain, myofascial pain, neuralgia, and irritable bowel syndrome.[A191083,L11878]
Marketing Status approved
ATC Code N06AA10
DrugBank ID DB00540
KEGG ID D08288
MeSH ID D009661
PubChem ID 4543
TTD Drug ID D04WFD
NDC Product Code Not Available
UNII BL03SY4LXB
Synonyms Nortriptyline | Desitriptyline | Desmethylamitriptylin | Allegron | Apo-Nortriptyline | Apo Nortriptyline | Aventyl | Gen-Nortriptyline | Gen Nortriptyline | Paxtibi | Nortrilen | Nortriptyline Hydrochloride | Hydrochloride, Nortriptyline | Novo-Nortriptyline | Novo Nortriptyline | Nu-Nortriptyline | Nu Nortriptyline | Pamelor | PMS-Nortriptyline | PMS Nortriptyline | ratio-Nortriptyline | ratio Nortriptyline | Norfenazin
Chemical Information
Molecular Formula C19H21N
CAS Registry Number 72-69-5
SMILES CNCCC=C1C2=CC=CC=C2CCC3=CC=CC=C31
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal distension07.01.04.0010.000261%
Abdominal pain07.01.05.002--
Abdominal pain upper07.01.05.003--
Accommodation disorder06.02.04.001--Not Available
Agitation17.02.05.012; 19.06.02.001--
Agranulocytosis01.02.03.001--Not Available
Alopecia23.02.02.001--
Angle closure glaucoma06.03.01.001--Not Available
Anxiety19.06.02.0020.000261%
Aplastic anaemia01.03.03.002--Not Available
Arrhythmia02.03.02.001--Not Available
Asthenia08.01.01.0010.000261%Not Available
Ataxia17.02.02.001; 08.01.02.004--
Atrioventricular block02.03.01.002--Not Available
Body temperature increased13.15.01.001--Not Available
Bradycardia02.03.02.0020.000119%Not Available
Breast enlargement21.05.04.001--Not Available
Bundle branch block02.03.01.009--Not Available
Burning sensation17.02.06.001; 08.01.09.029--Not Available
Cerebrovascular accident24.03.05.001; 17.08.01.007--
Cholestasis09.01.01.001--Not Available
Clumsiness17.01.02.005--Not Available
Colitis ulcerative10.02.01.004; 07.08.01.005--Not Available
Completed suicide19.12.01.001; 08.04.01.0100.001365%Not Available
Conduction disorder02.03.01.008--
Confusional state17.02.03.005; 19.13.01.001--
Constipation07.02.02.0010.000261%
Coordination abnormal17.02.02.004--Not Available
Delirium19.13.02.001--
Delusion19.10.01.001--
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ADReCS-Target
Drug Name ADR Term Target
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