Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Vitamin b12
Drug ID BADD_D02408
Description Cyanocobalamin (commonly known as Vitamin B12) is a highly complex, essential vitamin, owing its name to the fact that it contains the mineral, cobalt. This vitamin is produced naturally by bacteria [A175276], and is necessary for DNA synthesis and cellular energy production. Vitamin B12 has many forms, including the cyano-, methyl-, deoxyadenosyl- and hydroxy-cobalamin forms. The _cyano_ form, is the most widely used form in supplements and prescription drugs [A175255], [FDA label]. Several pharmaceutical forms of cyanocobalamin have been developed, including the tablet, injection, and nasal spray forms [FDA label], [L5542], [L5545]. This drug was initially approved by the FDA in 1942 [FDA label].
Indications and Usage Not Available
Marketing Status Not Available
ATC Code V09XX02
DrugBank ID DB00115
KEGG ID D03616
MeSH ID D014805
PubChem ID 23806828
TTD Drug ID D0FR6I
NDC Product Code 0517-0032; 49884-270; 51662-1394; 52584-399; 70529-290; 82298-201; 63323-044; 70069-005; 51552-1045; 0143-9621; 55150-364; 70069-171; 72843-507; 0395-8140; 16729-533; 70069-172; 0404-9840; 72843-487; 51927-1662; 50090-2709; 69680-112; 68083-449; 76420-111; 50396-7800; 69680-121; 0517-0130; 81376-303; 40074-0013; 51662-1440; 69680-113; 70529-293; 72843-497; 0517-0031; 76420-075; 63238-3700; 0143-9619; 0143-9620; 68001-509
Synonyms Vitamin B 12 | B 12, Vitamin | Vitamin B12 | B12, Vitamin | Cyanocobalamin | Cobalamins | Cobalamin | Eritron
Chemical Information
Molecular Formula C63H89CoN14O14P+
CAS Registry Number 68-19-9
SMILES CC1=CC2=C(C=C1C)N(C=N2)C3C(C(C(O3)CO)OP(=O)(O)OC(C)CNC(=O)CCC4(C(C5C6(C(C(C(=C(C 7=NC(=CC8=NC(=C(C4=N5)C)C(C8(C)C)CCC(=O)N)C(C7(C)CC(=O)N)CCC(=O)N)C)[N-]6)CCC(=O )N)(C)CC(=O)N)C)CC(=O)N)C)O.[C-]#N.[Co+3]
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abscess11.01.08.0010.000350%Not Available
Anaphylactic reaction24.06.03.006; 10.01.07.0010.000526%
Angioedema23.04.01.001; 10.01.05.0090.000350%Not Available
Arthralgia15.01.02.0010.000350%
Cardiac failure congestive02.05.01.0020.000350%Not Available
Chorea17.01.01.0010.000350%Not Available
Dermatitis acneiform23.02.01.0040.000526%
Disturbance in attention19.21.02.002; 17.03.03.0010.000350%
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.0040.000876%
Drug hypersensitivity10.01.01.0010.000526%Not Available
Dyskinesia17.01.02.0060.000350%
Dysphagia07.01.06.0030.000701%
Dyspnoea22.02.01.004; 02.01.03.0020.000350%
Endocarditis11.01.16.001; 02.09.01.0010.000350%
Epistaxis22.04.03.001; 24.07.01.0050.000526%
Fatigue08.01.01.0020.000526%
Flushing24.03.01.002; 23.06.05.003; 08.01.03.0250.000350%
Haemoglobin decreased13.01.05.0030.000350%Not Available
Headache17.14.01.0010.000526%
Hypersensitivity10.01.03.0030.000526%
Hypoaesthesia17.02.06.0230.000526%Not Available
Hypokalaemia14.05.03.0020.000350%
Hyponatraemia14.05.04.0020.000350%
Lethargy19.04.04.004; 17.02.04.003; 08.01.01.0080.000526%
Mitral valve incompetence02.07.01.0020.000350%Not Available
Myalgia15.05.02.0010.000350%
Nausea07.01.07.0010.000350%
Pain08.01.08.0040.000350%
Pallor24.03.04.001; 23.03.03.031; 08.01.03.0320.000350%Not Available
Palpitations02.01.02.0030.000350%
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