Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Vancomycin hydrochloride
Drug ID BADD_D02333
Description Antibacterial obtained from Streptomyces orientalis. It is a glycopeptide related to ristocetin that inhibits bacterial cell wall assembly and is toxic to kidneys and the inner ear. As of January 29 2018, CutisPharma's Firvanq is the only FDA approved vancomycin oral liquid treatment option available for the the treatment of _Clostridium difficile_ associated diarrhea and enterocolitis caused by _Staphylococcus aureus_, including methicillin-resistant strains [LP1196]. Such an oral liquid formulation is expected to make _Clostridium difficile_ associated diarrhea therapy more accessible in comparison to previously available specialty compounding products [LP1196].
Indications and Usage Additionally, a unique FDA approved oral liquid treatment is also available and indicated for the treatment of Clostridium difficile associated diarrhea and enterocolitis caused by _Staphylococcus aureus_, including methicillin-resistant strains [L1196].
Marketing Status Prescription; Discontinued
ATC Code A07AA09; J01XA01; S01AA28
DrugBank ID DB00512
KEGG ID D00926
MeSH ID D014640
PubChem ID 6420023
TTD Drug ID D0B5GS
NDC Product Code 0338-3581; 0143-9356; 62559-311; 55150-205; 55150-206; 0409-6509; 42513-0006; 55150-204; 0409-6535; 63323-284; 51927-0069; 0143-9358; 70860-105; 0409-5017; 17478-741; 68001-407; 0338-3551; 0338-3552; 67457-824; 67457-340; 51927-0199; 63323-221; 70594-046; 63323-295; 67457-342; 0409-1319; 0143-9359; 65628-015; 67254-717; 63629-1971; 0409-6531; 55150-203; 63323-314; 62559-390; 0409-3515; 68001-465; 76333-265; 68083-143; 55500-0004; 70436-021; 47781-729; 0409-6510; 45932-0010; 0409-6533; 0404-9965; 38779-0274; 52972-0039; 45932-0009; 72572-801; 0409-4332; 76333-264; 65628-206; 0121-0867; 62991-2522; 47781-730; 67457-339; 70436-023; 0121-0890; 0338-3582; 68001-406; 72572-805; 67457-341; 65628-205; 66288-7100; 17478-742; 62559-391; 68180-166; 0409-6534; 52584-332; 72572-803; 62559-310; 70436-022; 63629-1970; 44231-0001; 72611-765; 63323-203; 65628-204; 63629-1972; 70436-020; 0338-3580; 67457-705; 0143-9355; 68083-144; 72611-761; 49452-8094; 70594-045; 68254-0006; 70594-047; 65628-208; 65628-016; 68180-167; 25021-158; 70860-104; 0338-3583; 70594-048; 67457-823; 68001-466; 62559-830; 25021-157; 0143-9357
Synonyms Vancomycin | Vancomycin Hydrochloride | Hydrochloride, Vancomycin | Vancomycin Sulfate | Sulfate, Vancomycin | Vancomycin-ratiopharm | Vancomycin Hexal | Vancomycine Dakota | AB-Vancomycin | Vanco Azupharma | Diatracin | VANCO-cell | Vanco-saar | Vancocin | Vancocin HCl | Vancomycin Lilly | Vancocine | Vancomicina Abbott | Vancomicina Chiesi | Vancomicina Combino Phar | Vancomicina Norman | Vancomycin Phosphate (1:2) | Vancomycin Phosphate (1:2), Decahydrate
Chemical Information
Molecular Formula C66H76Cl3N9O24
CAS Registry Number 1404-93-9
SMILES CC1C(C(CC(O1)OC2C(C(C(OC2OC3=C4C=C5C=C3OC6=C(C=C(C=C6)C(C(C(=O)NC(C(=O)NC5C(=O)N C7C8=CC(=C(C=C8)O)C9=C(C=C(C=C9O)O)C(NC(=O)C(C(C1=CC(=C(O4)C=C1)Cl)O)NC7=O)C(=O) O)CC(=O)N)NC(=O)C(CC(C)C)NC)O)Cl)CO)O)O)(C)N)O.Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Pseudomembranous colitis11.02.02.002; 07.19.01.003--Not Available
Pyrexia08.05.02.003--
Rash23.03.13.001--Not Available
Red man syndrome23.03.06.011; 10.01.01.013--Not Available
Renal failure20.01.03.005--Not Available
Skin disorder23.03.03.007--Not Available
Stevens-Johnson syndrome12.03.01.014; 11.07.01.005; 10.01.03.020; 23.03.01.007--
Thrombocytopenia01.08.01.002--Not Available
Tinnitus04.04.01.002; 17.04.07.004--
Toxic epidermal necrolysis23.03.01.008; 12.03.01.015; 11.07.01.006; 10.01.01.006--
Urticaria10.01.06.001; 23.04.02.001--
Vasculitis24.05.02.001; 10.02.02.006--
Vertigo17.02.12.002; 04.04.01.003--
Wheezing22.03.01.009--
Tubulointerstitial nephritis20.05.02.002--Not Available
Hypoacusis04.02.01.006--
Inflammation08.01.05.007--Not Available
Renal impairment20.01.03.010--Not Available
Acute kidney injury20.01.03.016--
Chemical peritonitis12.03.02.002; 07.07.01.002--Not Available
Drug reaction with eosinophilia and systemic symptoms23.03.05.005; 10.01.01.021--Not Available
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