Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Triamcinolone diacetate
Drug ID BADD_D02273
Description Triamcinolone is a corticosteroid used to treat various inflammatory conditions in the body from allergic rhinitis to acute exacerbations of multiple sclerosis.[L8255] Triamcinolone can be used as a one time adjunct treatment of osteoarthritic knee pain,[L8264] or first line as a topical treatment of corticosteroid responsive dermatoses.[L8249] Triamcinolone is more commonly seen in the forms triamcinolone hexacetonide, triamcinolone acetonide, and triamcinolone diacetate.[L8246,L8249,L8252,L8255,L8258,L8261,L8264] Triamcinolone was granted FDA approval on 3 December 1957.[L8243] In October 2021, a suspension of triamcinolone acetonide was approved for suprachoroidal injection - the first suprachoroidal injection to receive FDA approval[L38973] - for the treatment of patients with macular edema associated with uveitis.[L38963]
Indications and Usage For the treatment of perennial and seasonal allergic rhinitis.
Marketing Status Discontinued
ATC Code A01AC01; C05AA12; D07AB09; D07XB02; H02AB08; R01AD11; R03BA06; S01BA05
DrugBank ID DB00620
KEGG ID D00984
MeSH ID C030262
PubChem ID 6216
TTD Drug ID Not Available
NDC Product Code 38779-0166; 46439-8766; 52128-171; 62991-2175; 49452-7910
Synonyms triamcinolone diacetate | Polcartolone | Polcortolon
Chemical Information
Molecular Formula C25H31FO8
CAS Registry Number 67-78-7
SMILES CC(=O)OCC(=O)C1(C(CC2C1(CC(C3(C2CCC4=CC(=O)C=CC43C)F)O)C)OC(=O)C)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Glycosuria20.02.01.005--
Headache17.14.01.001--
Hepatomegaly09.01.05.001--Not Available
Hiccups22.02.04.002; 07.01.06.009--
Hirsutism23.02.04.001; 05.05.01.005--
Hyperhidrosis08.01.03.028; 23.02.03.004--
Hypersensitivity10.01.03.003--
Hypertension24.08.02.001--
Hypertrichosis23.02.04.002--
Hypertrophic cardiomyopathy03.07.02.004; 02.04.01.002--Not Available
Hypopituitarism05.03.02.001--
Impaired healing08.03.02.001--Not Available
Increased appetite08.01.09.027; 14.03.01.003--Not Available
Injection site infection12.07.03.008; 11.01.08.005; 08.02.03.019--Not Available
Insomnia19.02.01.002; 17.15.03.002--
Intracranial pressure increased17.07.02.002--Not Available
Malaise08.01.01.003--
Meningitis17.06.03.001; 11.01.03.001--
Menstruation irregular21.01.01.005; 05.05.01.008--
Mood swings19.04.03.001--Not Available
Muscular weakness17.05.03.005; 15.05.06.001--
Myocardial rupture02.04.02.002; 12.01.11.002--Not Available
Myopathy15.05.05.001--Not Available
Nausea07.01.07.001--
Neuritis17.09.03.001--Not Available
Neuropathic arthropathy17.09.03.008; 15.01.01.007--Not Available
Neuropathy peripheral17.09.03.003--Not Available
Nitrogen balance negative13.13.01.010--Not Available
Oedema14.05.06.010; 08.01.07.006--Not Available
Osteonecrosis24.04.05.004; 15.02.04.007--
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