Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Treprostinil
Drug ID BADD_D02268
Description Treprostinil is a synthetic analogue of prostacyclin, used to treat pulmonary hypertension.
Indications and Usage For use as a continuous subcutaneous infusion or intravenous infusion (for those not able to tolerate a subcutaneous infusion) for the treatment of pulmonary arterial hypertension in patients with NYHA Class II-IV symptoms to diminish symptoms associated with exercise.
Marketing Status Prescription
ATC Code B01AC21
DrugBank ID DB00374
KEGG ID D06213
MeSH ID C427248
PubChem ID 6918140
TTD Drug ID D01WUA
NDC Product Code 0703-0696; 62332-516; 68245-0008; 0703-0666; 0703-0686; 0781-3427; 58159-041; 0781-3420; 66302-120; 0703-0676; 62332-515; 66302-110; 42023-206; 42023-208; 42023-207; 62332-517; 11014-0094; 81861-0029; 62332-514; 66302-102; 54893-0024; 66302-300; 66302-302; 14501-0015; 66302-206; 0781-3425; 66302-350; 66302-105; 66302-101; 42023-209; 0781-3430; 66302-310; 66302-325
Synonyms treprostinil | ((1R,2R,3AS,9AS)-2-hydroxy-1-((3S)-3-hydroxyoctyl)-2,3,3A,4,9,9A-hexahydro-1H-cylopent(b)naphthalen-5-yl)oxy)acetate | treprostinil sodium | trepostinil sodium | Orenitram | UT-15 | UT-15C | Remodulin | treprostinil diolamine | treprostinil diolamin | treprostinil diethanolamine
Chemical Information
Molecular Formula C23H34O5
CAS Registry Number 81846-19-7
SMILES CCCCCC(CCC1C(CC2C1CC3=C(C2)C(=CC=C3)OCC(=O)O)O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Kidney infection20.01.09.004; 11.01.14.0060.000556%
Laceration23.03.11.004; 12.01.06.006--Not Available
Lacrimation increased06.08.02.004--
Laryngeal pain22.02.05.036--
Left ventricular failure02.05.02.0010.000371%Not Available
Lethargy19.04.04.004; 17.02.04.003; 08.01.01.0080.002782%
Liver disorder09.01.08.001--Not Available
Local swelling08.01.03.0130.001113%Not Available
Localised infection11.01.08.0060.000927%Not Available
Loss of consciousness17.02.04.0040.007420%Not Available
Lower respiratory tract infection22.07.01.002; 11.01.09.0020.000742%Not Available
Lung disorder22.02.07.0010.001669%Not Available
Lymphadenopathy01.09.01.002--Not Available
Lymphoedema24.09.01.001; 01.09.01.0060.000371%
Malabsorption07.17.01.001; 14.02.01.0040.000371%
Malaise08.01.01.0030.018179%
Melaena24.07.02.013; 07.12.02.004--Not Available
Memory impairment19.20.01.003; 17.03.02.003--
Meningitis17.06.03.001; 11.01.03.0010.000097%
Metabolic acidosis14.01.01.003--Not Available
Micturition urgency20.02.02.0060.000371%
Migraine24.03.05.003; 17.14.02.0010.003524%Not Available
Muscle spasms15.05.03.004--
Muscular weakness17.05.03.005; 15.05.06.001--
Musculoskeletal pain15.03.04.0070.002411%
Myalgia15.05.02.001--
Myelodysplastic syndrome16.01.04.001; 01.10.04.001--
Myocardial infarction24.04.04.009; 02.02.02.007--
Nasal congestion22.04.04.0010.004081%
Nasopharyngitis22.07.03.002; 11.01.13.0020.008533%Not Available
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