Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Treprostinil
Drug ID BADD_D02268
Description Treprostinil is a synthetic analogue of prostacyclin, used to treat pulmonary hypertension.
Indications and Usage For use as a continuous subcutaneous infusion or intravenous infusion (for those not able to tolerate a subcutaneous infusion) for the treatment of pulmonary arterial hypertension in patients with NYHA Class II-IV symptoms to diminish symptoms associated with exercise.
Marketing Status approved; investigational
ATC Code B01AC21
DrugBank ID DB00374
KEGG ID D06213
MeSH ID C427248
PubChem ID 6918140
TTD Drug ID D01WUA
NDC Product Code 0703-0696; 0781-3430; 11014-0094; 66302-350; 66302-648; 66302-748; 66302-361; 66302-363; 66302-620; 66302-720; 0703-0676; 43598-646; 43598-647; 66302-302; 66302-325; 66302-616; 66302-362; 0703-0666; 14501-0015; 42023-209; 62332-515; 66302-110; 66302-300; 66302-610; 54893-0024; 43598-649; 62332-514; 62332-517; 66302-102; 66302-206; 66302-732; 58159-041; 68245-0008; 43598-648; 66302-120; 66302-600; 66302-650; 66302-764; 0703-0686; 0781-3420; 0781-3425; 81861-0029; 66302-101; 66302-310; 66302-630; 66302-664; 0781-3427; 42023-206; 66302-105; 66302-640; 42023-207; 62332-516; 66302-632; 66302-716; 42023-208
UNII RUM6K67ESG
Synonyms treprostinil | ((1R,2R,3AS,9AS)-2-hydroxy-1-((3S)-3-hydroxyoctyl)-2,3,3A,4,9,9A-hexahydro-1H-cylopent(b)naphthalen-5-yl)oxy)acetate | treprostinil sodium | trepostinil sodium | Orenitram | UT-15 | UT-15C | Remodulin | treprostinil diolamine | treprostinil diolamin | treprostinil diethanolamine
Chemical Information
Molecular Formula C23H34O5
CAS Registry Number 81846-19-7
SMILES CCCCCC(CCC1C(CC2C1CC3=C(C2)C(=CC=C3)OCC(=O)O)O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Pruritus23.03.12.001--
Pulmonary congestion02.05.02.002; 24.03.08.001; 22.01.03.0020.000082%Not Available
Pulmonary embolism24.01.06.001; 22.06.02.001--Not Available
Pulmonary fibrosis22.01.02.0060.000370%
Pulmonary haemorrhage22.12.01.009; 24.07.01.0160.000329%
Pulmonary hypertension24.08.03.002; 22.06.01.0010.007344%
Pulmonary oedema22.01.03.003; 02.05.02.0030.002138%
Pulmonary thrombosis24.01.06.002; 22.06.02.0030.000206%Not Available
Pulmonary veno-occlusive disease24.01.06.008; 22.06.03.0030.000535%Not Available
Pyrexia08.05.02.0030.007632%
Rales22.12.01.0110.000880%Not Available
Rash23.03.13.001--Not Available
Raynaud's phenomenon24.04.03.0030.000082%Not Available
Rectal haemorrhage24.07.02.018; 07.12.03.001--
Renal failure20.01.03.0050.001686%Not Available
Respiration abnormal22.02.01.0410.002221%Not Available
Respiratory arrest22.02.01.0090.000452%Not Available
Respiratory disorder22.02.07.0020.001119%Not Available
Respiratory distress22.02.01.0120.001563%Not Available
Respiratory failure22.02.06.002; 14.01.04.0030.004688%
Retching07.01.07.0020.001143%Not Available
Retroperitoneal haemorrhage12.01.17.018; 24.07.01.017; 07.07.02.0020.000082%
Rhinitis22.07.03.006; 11.01.13.004--
Rhinorrhoea22.12.03.0210.001341%
Right ventricular failure02.05.03.0020.004606%Not Available
Rotator cuff syndrome12.01.07.018; 15.01.08.0020.000082%
Scleroderma10.04.07.001; 23.03.02.005; 15.06.01.0020.000452%Not Available
Sepsis11.01.11.003--
Shock24.06.02.0020.000370%Not Available
Sickle cell anaemia with crisis01.04.02.0010.000617%Not Available
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ADReCS-Target
Drug Name ADR Term Target
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