Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Toremifene citrate
Drug ID BADD_D02250
Description A first generation nonsteroidal selective estrogen receptor modulator (SERM) that is structurally related to tamoxifen. Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
Indications and Usage For the treatment of metastatic breast cancer in postmenopausal women with estrogen receptor-positive or receptor-unknown tumors. Toremifene is currently under investigation as a preventative agent for prostate cancer in men with high-grade prostatic intraepithelial neoplasia and no evidence of prostate cancer.
Marketing Status Prescription
ATC Code L02BA02
DrugBank ID DB00539
KEGG ID D00967
MeSH ID D017312
PubChem ID 3005572
TTD Drug ID D04VFJ
NDC Product Code 69539-152; 64980-404; 52483-0060; 54893-0079; 17337-0305; 73309-291; 72205-050; 42747-327
Synonyms Toremifene | Toremifene, (E)-Isomer | Toremifene Citrate | Citrate, Toremifene | Toremifene Citrate (1:1) | Fareston | FC-1157a | FC 1157a | FC1157a
Chemical Information
Molecular Formula C32H36ClNO8
CAS Registry Number 89778-27-8
SMILES CN(C)CCOC1=CC=C(C=C1)C(=C(CCCl)C2=CC=CC=C2)C3=CC=CC=C3.C(C(=O)O)C(CC(=O)O)(C(=O) O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Fatigue08.01.01.002--
Gastrointestinal disorder07.11.01.001--Not Available
Glaucoma06.03.01.002--
Headache17.14.01.001--
Hepatitis toxic12.03.01.016; 09.01.07.017--Not Available
Hepatocellular injury09.01.07.008--Not Available
Hepatotoxicity12.03.01.008; 09.01.07.009--Not Available
Hypercalcaemia14.04.01.003; 05.04.01.002--
Hyperhidrosis23.02.03.004; 08.01.03.028--
Insomnia19.02.01.002; 17.15.03.002--
Jaundice23.03.03.030; 09.01.01.004; 01.06.04.004--Not Available
Keratopathy06.06.03.007--Not Available
Lethargy19.04.04.004; 17.02.04.003; 08.01.01.008--
Leukopenia01.02.02.001--Not Available
Liver disorder09.01.08.001--Not Available
Liver function test abnormal13.03.01.013--Not Available
Menopausal symptoms21.02.02.002--Not Available
Mood swings19.04.03.001--Not Available
Myocardial infarction24.04.04.009; 02.02.02.007--
Nausea07.01.07.001--
Nervous system disorder17.02.10.001--Not Available
Neuropathy peripheral17.09.03.003--Not Available
Oedema14.05.06.010; 08.01.07.006--Not Available
Pain08.01.08.004--
Paresis17.01.04.008--Not Available
Pruritus23.03.12.001--
Pulmonary embolism24.01.06.001; 22.06.02.001--Not Available
Rash23.03.13.001--Not Available
Skin discolouration23.03.03.005--Not Available
Skin disorder23.03.03.007--Not Available
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