| Pharmaceutical Information |
| Drug Name |
Tiludronate disodium |
| Drug ID |
BADD_D02218 |
| Description |
Tiludronate, or (4-chlorophenyl)thio-methylene-1,1-bisphosphonate, is a first generation bisphosphonate similar to [etidronic acid] and [clodronic acid].[A1923,A203111] These drugs were developed to mimic the action of pyrophosphate, a regulator of calcification and decalcification.[A1923] Tiludronic acid was first described in the literature in 1988 as a potential treatment for Paget's disease of bone.[A202235]
Tiludronic acid was granted FDA approval on 7 March 1997.[L4763] |
| Indications and Usage |
For treatment of Paget's disease of bone (osteitis deformans). |
| Marketing Status |
Discontinued |
| ATC Code |
M05BA05 |
| DrugBank ID |
DB01133
|
| KEGG ID |
D02285
|
| MeSH ID |
C058651
|
| PubChem ID |
60936
|
| TTD Drug ID |
D0Q8CS
|
| NDC Product Code |
Not Available |
| Synonyms |
tiludronic acid | (4-chlorophenyl)thiomethylene bisphosphonic acid | Cl2SMBP | tiludronate | (chloro-4-phenyl)thiomethylene biphosphonate | (chloro-4-phenyl)thiomethylene bisphosphonate | tiludronate disodium | Skelid |
|
| Chemical Information |
| Molecular Formula |
C7H7ClNa2O6P2S |
| CAS Registry Number |
149845-07-8 |
| SMILES |
C1=CC(=CC=C1SC(P(=O)(O)[O-])P(=O)(O)[O-])Cl.[Na+].[Na+] |
| Chemical Structure |
|
|
| ADR Related Proteins Induced by Drug |
| ADR Term |
Protein Name |
UniProt AC |
TTD Target ID |
PMID |
| Not Available | Not Available | Not Available | Not Available | Not Available |
|
| ADRs Induced by Drug |
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