Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Sibutramine
Drug ID BADD_D02016
Description Sibutramine (trade name Meridia in the USA, Reductil in Europe and other countries), usually as sibutramide hydrochloride monohydrate, is an orally administered agent for the treatment of obesity. It is a centrally acting stimulant chemically related to amphetamines thus it is classified as a Schedule IV controlled substance in the United States. In October 2010, Sibutramine was withdrawn from Canadian and U.S. markets due to concerns that the drug increases the risk of heart attack and stroke in patients with a history of heart disease.
Indications and Usage For the treatment of obesity.
Marketing Status Discontinued
ATC Code A08AA10
DrugBank ID DB01105
KEGG ID D08513
MeSH ID C058254
PubChem ID 5210
TTD Drug ID D08KVZ
NDC Product Code Not Available
Synonyms sibutramine | di-desmethylsibutramine | didesmethylsibutramine | (R)-DDMS | Reductil | mono-desmethylsibutramine | sibutramine hydrochloride | N-1-(1-(4-chlorophenyl)cyclobutyl)-3-methylbutyl-N,N-dimethylamine HCl | BTS 54 524 | BTS-54524 | BTS 54524 | Meridia
Chemical Information
Molecular Formula C17H26ClN
CAS Registry Number 106650-56-0
SMILES CC(C)CC(C1(CCC1)C2=CC=C(C=C2)Cl)N(C)C
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Gastrointestinal haemorrhage24.07.02.009; 07.12.02.001--Not Available
Gastrointestinal pain07.01.05.005--
Generalised oedema14.05.06.007; 08.01.07.004--
Gingivitis11.01.04.013; 07.09.03.003--
Glaucoma06.03.01.002--
Glomerulonephritis membranoproliferative20.05.01.012--Not Available
Glossitis07.14.01.001--Not Available
Goitre14.11.01.008; 05.02.01.001--Not Available
Gout15.01.06.001; 14.09.01.001--Not Available
Haematuria20.02.01.006; 24.07.01.047--
Haemoglobin13.01.05.018--Not Available
Haemorrhoids24.10.02.002; 07.15.03.001--
Hair disorder23.02.06.003--Not Available
Hallucinations, mixed19.10.02.007--Not Available
Hangover08.01.09.018--Not Available
Headache17.14.01.001--
Henoch-Schonlein purpura24.07.06.003; 23.06.01.002; 10.02.02.004; 01.01.04.001--Not Available
Hepatic function abnormal09.01.02.001--Not Available
Hepatic steatosis14.08.04.005; 09.01.07.003--Not Available
Hernia08.01.04.001--Not Available
Herpes simplex23.09.03.001; 11.05.02.001--Not Available
Herpes zoster23.09.03.002; 11.05.02.003--
Hostility19.05.01.003--Not Available
Hyperbilirubinaemia14.11.01.010; 09.01.01.003; 01.06.04.003--Not Available
Hypercholesterolaemia14.08.01.001--Not Available
Hyperglycaemia14.06.02.002; 05.06.02.002--
Hyperhidrosis08.01.03.028; 23.02.03.004--
Hyperkalaemia14.05.03.001--
Hyperkinesia17.01.02.008--Not Available
Hypersensitivity10.01.03.003--
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