Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Sertraline hydrochloride
Drug ID BADD_D02011
Description Sertraline is a popular antidepressant medication commonly known as a selective serotonin reuptake inhibitor (SSRI), and is similar to drugs such as [Citalopram] and [Fluoxetine]. Despite marked structural differences between compounds in this drug class, SSRIs exert similar pharmacological effects. Several weeks of therapy with sertraline may be required before beneficial effects are noticed. Sertraline displays enhanced safety or tolerability than other classes of antidepressants, which frequently cause high levels of drowsiness, dizziness, blurred vision, and other undesirable effects.[A1846,A187075,T28]
Indications and Usage It may be used for premature ejaculation and vascular headaches as off-label indications.
Marketing Status Prescription; Discontinued
ATC Code N06AB06
DrugBank ID DB01104
KEGG ID D00825
MeSH ID D020280
PubChem ID 63009
TTD Drug ID D0K0TC
NDC Product Code 16714-612; 55700-340; 43602-979; 53869-4900; 0049-4960; 68071-4029; 71093-129; 65841-044; 65841-043; 50090-2080; 72865-205; 45865-518; 59762-0067; 71205-343; 65015-821; 43602-980; 61919-345; 46144-108; 55700-910; 68071-3071; 53002-3192; 70518-0094; 0049-4900; 65862-013; 70518-1350; 63187-859; 72789-088; 68071-4658; 65977-0056; 68071-3146; 64980-409; 61919-014; 43353-970; 53002-1507; 50090-3203; 68071-4993; 68788-8109; 71205-028; 31722-147; 43063-855; 65841-045; 51655-265; 68071-1911; 60760-737; 71205-455; 71205-205; 68071-4973; 53104-7590; 50436-0217; 53808-1127; 65862-222; 50090-2976; 50436-0216; 16729-216; 60687-242; 53002-1192; 70518-3145; 43353-447; 68071-2496; 67046-559; 55700-948; 65862-011; 60760-738; 51655-345; 71610-433; 68788-6429; 68788-7928; 72189-122; 60687-253; 65862-012; 61919-086; 42708-124; 71610-106; 53002-4215; 43063-033; 71093-143; 51655-173; 63629-8774; 63629-8127; 70934-192; 71335-0328; 60760-091; 69097-833; 71335-0210; 65977-0002; 53002-3215; 65862-224; 68071-4462; 55700-362; 71335-0415; 72865-206; 68071-3309; 55289-409; 50090-3945; 31722-146; 71093-130; 67046-554; 50090-3153; 71335-0808; 53869-4960; 68071-1318; 55154-4687; 58118-0834; 53002-2507; 55154-4692; 62350-0043; 70934-190; 71610-435; 71335-0403; 53104-7578; 16729-217; 43063-754; 68071-4370; 70518-1748; 16714-613; 68788-6835; 72789-013; 70518-2448; 70934-169; 71093-131; 0049-4910; 70518-1913; 68645-521; 69097-834; 72865-207; 53869-4910; 63187-795; 31722-145; 60760-612; 43602-981; 16714-601; 71205-047; 50090-2609; 71335-1078; 77777-108; 71335-0718; 16729-215; 52427-672; 68071-1317; 71335-0510; 0143-9655; 70518-2812; 68788-6437; 0049-0050; 68071-4750; 50090-3947; 69097-835; 63187-767; 60687-231; 50436-0215; 71335-0896; 42708-092; 55111-968; 70518-2706; 53002-1215; 72789-092; 52427-664; 16714-611; 68645-523; 55700-562; 68071-4494; 68645-522
Synonyms Sertraline | Zoloft | Altruline | Lustral | Apo-Sertraline | Apo Sertraline | Aremis | Besitran | Sealdin | Gladem | Novo-Sertraline | Novo Sertraline | ratio-Sertraline | ratio Sertraline | Rhoxal-sertraline | Rhoxal sertraline | Sertraline Hydrochloride | Hydrochloride, Sertraline | Sertraline Hydrochloride (1S-cis)-Isomer | Gen-Sertraline | Gen Sertraline
Chemical Information
Molecular Formula C17H18Cl3N
CAS Registry Number 79559-97-0
SMILES CNC1CCC(C2=CC=CC=C12)C3=CC(=C(C=C3)Cl)Cl.Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Poisoning and toxicityCytochrome P450 2D6P10635T57392Not Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Haemorrhoids24.10.02.002; 07.15.03.001--
Hair texture abnormal23.02.06.004--
Hallucination19.10.02.002--
Headache17.14.01.001--
Hepatic adenoma09.04.01.002; 16.06.01.002--Not Available
Hepatic failure09.01.03.002--
Hepatic function abnormal09.01.02.001--Not Available
Hepatitis09.01.07.004--Not Available
Hepatomegaly09.01.05.001--Not Available
Hernia08.01.04.001--Not Available
Hiccups22.02.04.002; 07.01.06.009--
Hostility19.05.01.003--Not Available
Hyperacusis17.04.03.003; 04.02.02.001--Not Available
Hyperaesthesia17.02.06.004--Not Available
Hypercholesterolaemia14.08.01.001--Not Available
Hyperglycaemia14.06.02.002; 05.06.02.002--
Hyperhidrosis08.01.03.028; 23.02.03.004--
Hyperkinesia17.01.02.008--Not Available
Hyperplasia08.03.04.008--Not Available
Hyperprolactinaemia05.03.01.002--Not Available
Hypersensitivity10.01.03.003--
Hypertension24.08.02.001--
Hypertonia17.05.02.001; 15.05.04.007--Not Available
Hypertrichosis23.02.04.002--
Hypertrophy08.03.04.005--Not Available
Hyperventilation22.02.01.006; 19.01.02.004--Not Available
Hyphaema24.07.05.004; 12.01.04.007; 06.07.04.001--Not Available
Hypoaesthesia17.02.06.023--Not Available
Hypoglycaemia05.06.03.001; 14.06.03.001--
Hypokinesia17.01.02.009--Not Available
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