Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Ropivacaine hydrochloride
Drug ID BADD_D01968
Description Ropivacaine is an aminoamide local anaesthetic drug commonly marketed by AstraZeneca under the trade name Naropin. It is present as a racemic mixture of the enantiomers containing equal proportions of the “S” and “R” forms. The marketed form contains the single S-enantiomer as the active ingredient.
Indications and Usage Used in obstetric anesthesia and regional anesthesia for surgery.
Marketing Status Prescription; Discontinued
ATC Code N01BB09
DrugBank ID DB00296
KEGG ID D04048
MeSH ID D000077212
PubChem ID 175804
TTD Drug ID D09RHQ
NDC Product Code 70069-063; 43066-015; 0409-9300; 65145-108; 43066-023; 55150-201; 63323-285; 55150-196; 63323-286; 55150-195; 46014-1058; 25021-671; 0409-9301; 65145-109; 63323-287; 55150-198; 70518-2681; 63323-288; 49386-025; 55150-199; 65145-107; 48954-722; 0143-9265; 67184-0022; 25021-652; 0143-9263; 70069-061; 55150-197; 76339-124; 0404-9924; 70069-064; 17478-081; 43066-019; 51552-1590; 70516-0165; 0143-9264; 0409-9302; 49452-6303; 0143-9266; 52584-286; 43066-027; 65372-1159; 70069-062; 17478-082; 65145-110; 0409-9303; 61876-0071; 55150-200; 70069-065; 70069-066; 70069-067
Synonyms Ropivacaine | 1-Propyl-2',6'-pipecoloxylidide | 1 Propyl 2',6' pipecoloxylidide | Naropin | Ropivacaine Monohydrochloride | Ropivacaine Hydrochloride | AL 381 | AL-381 | AL381 | Naropeine | LEA 103 | LEA-103 | LEA103 | Ropivacaine Monohydrochloride, (S)-isomer
Chemical Information
Molecular Formula C17H27ClN2O
CAS Registry Number 98717-15-8
SMILES CCCN1CCCCC1C(=O)NC2=C(C=CC=C2C)C.Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Erythema23.03.06.001--Not Available
Extrasystoles02.03.02.003--Not Available
Eyelid ptosis17.17.02.004; 06.05.01.002--Not Available
Failed trial of labour18.07.03.002--Not Available
Feeling abnormal08.01.09.014--Not Available
Fever neonatal18.04.01.009; 08.05.02.007--Not Available
Foetal distress syndrome18.03.02.003--Not Available
Gastrointestinal pain07.01.05.005--
Generalised tonic-clonic seizure17.12.01.002--Not Available
Haematuria20.02.01.006; 24.07.01.047--
Hallucination19.10.02.002--
Headache17.14.01.001--
Heart disease congenital03.07.07.001; 02.01.01.009--Not Available
Hepatic function abnormal09.01.02.001--Not Available
Horner's syndrome17.05.01.004; 16.32.03.006; 06.09.04.002--Not Available
Hypercapnia22.02.02.002; 14.01.04.001--Not Available
Hyperglycaemia14.06.02.002; 05.06.02.002--
Hyperhidrosis08.01.03.028; 23.02.03.004--
Hyperkalaemia14.05.03.001--
Hypersensitivity10.01.03.003--
Hypertension24.08.02.001--
Hypoaesthesia17.02.06.023--Not Available
Hypocalcaemia14.04.01.004--
Hypoglycaemia14.06.03.001; 05.06.03.001--
Hypoglycaemia neonatal18.04.06.003; 14.06.03.006; 05.06.03.006--Not Available
Hypokalaemia14.05.03.002--
Hypokinesia17.01.02.009--Not Available
Hypomagnesaemia14.04.02.001--
Hypoproteinaemia14.10.01.003; 09.01.02.004--Not Available
Hypotension24.06.03.002--
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