Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Rivaroxaban
Drug ID BADD_D01954
Description Rivaroxaban is an anticoagulant and the first orally active direct factor Xa inhibitor. Unlike warfarin, routine lab monitoring of INR is not necessary. However there is no antidote available in the event of a major bleed. Only the 10 mg tablet can be taken without regard to food. The 15 mg and 20 mg tablet should be taken with food. FDA approved on July 1, 2011.
Indications and Usage Not Available
Marketing Status Prescription
ATC Code B01AF01
DrugBank ID DB06228
KEGG ID D07086
MeSH ID D000069552
PubChem ID 9875401
TTD Drug ID D0KG3R
NDC Product Code 50090-3625; 50458-579; 50458-575; 65015-898; 58032-2029; 55154-1424; 53296-0109; 14799-2023; 55111-966; 76072-1008; 47848-039; 55154-1423; 14501-0079; 65727-050; 52286-0025; 59285-009; 65862-971; 16436-0109; 75945-050; 50090-4468; 53104-7730; 50090-3639; 53747-068; 66022-0203; 50090-4469; 50458-580; 64220-176; 63415-0523; 64552-4049; 50458-578; 46708-899; 82513-0001; 66174-0087; 72969-109; 66039-913; 50458-584; 65372-1193; 50458-577; 55154-1422; 69218-0500
Synonyms Rivaroxaban | 5-chloro-N-(((5S)-2-oxo-3-(4-(3-oxomorpholin-4-yl)phenyl)-1,3-oxazolidin-5-yl)methyl)thiophene-2-carboxamide | Xarelto | BAY 59-7939 | BAY 59 7939 | BAY 597939
Chemical Information
Molecular Formula C19H18ClN3O5S
CAS Registry Number 366789-02-8
SMILES C1COCC(=O)N1C2=CC=C(C=C2)N3CC(OC3=O)CNC(=O)C4=CC=C(S4)Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Carpal tunnel syndrome17.09.02.001--Not Available
Cataract06.06.01.001--
Cellulitis23.09.01.001; 11.02.01.001--Not Available
Cerebellar infarction24.04.06.007; 17.08.01.0130.008210%Not Available
Cerebellar syndrome17.02.02.002--Not Available
Cerebral artery embolism17.08.01.001; 24.01.04.0010.002561%Not Available
Cerebral artery occlusion17.08.01.028; 24.04.06.0200.004819%Not Available
Cerebral atrophy17.11.01.001--Not Available
Cerebral haemorrhage24.07.04.001; 17.08.01.0030.034732%Not Available
Cerebral infarction24.04.06.002; 17.08.01.0040.127787%Not Available
Cerebral ischaemia24.04.06.003; 17.08.01.0050.003259%
Cerebral palsy18.04.04.004; 17.19.03.002; 03.10.03.0020.000357%Not Available
Cerebral thrombosis17.08.01.006; 24.01.04.0030.004105%Not Available
Cerebral venous thrombosis24.01.04.005; 17.08.03.002--Not Available
Cerebrovascular accident24.03.05.001; 17.08.01.0070.360515%
Cerebrovascular disorder17.08.02.002; 24.03.05.0020.000559%Not Available
Cervix carcinoma21.06.02.001; 16.12.01.0010.000714%Not Available
Chest discomfort22.02.08.001; 08.01.08.019; 02.02.02.009--Not Available
Chest pain22.02.08.003; 08.01.08.002; 02.02.02.011--Not Available
Chest X-ray abnormal13.19.02.001--Not Available
Chills15.05.03.016; 08.01.09.001--
Choking22.02.05.001--Not Available
Cholecystitis09.03.01.001--
Cholecystitis acute09.03.01.0030.001963%Not Available
Cholelithiasis09.03.01.002--Not Available
Cholestasis09.01.01.001--Not Available
Chondrocalcinosis pyrophosphate15.01.06.003; 14.04.01.0100.000714%Not Available
Chromaturia20.02.01.0020.007317%
Chronic hepatitis11.07.01.009; 09.01.07.0210.000357%Not Available
Chronic obstructive pulmonary disease22.03.01.007--Not Available
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