Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Rabeprazole
Drug ID BADD_D01898
Description Rabeprazole is an antiulcer drug in the class of proton pump inhibitors. It is a prodrug - in the acid environment of the parietal cells it turns into active sulphenamide form. Rabeprazole inhibits the H+, K+ATPase of the coating gastric cells and dose-dependent oppresses basal and stimulated gastric acid secretion.
Indications and Usage For the treatment of acid-reflux disorders (GERD), peptic ulcer disease, H. pylori eradication, and prevention of gastroinetestinal bleeds with NSAID use.
Marketing Status Prescription; Discontinued
ATC Code A02BC04
DrugBank ID DB01129
KEGG ID D08463
MeSH ID D064750
PubChem ID 5029
TTD Drug ID D0KL4J
NDC Product Code 65162-724
Synonyms Rabeprazole | 2-((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methylsulfinyl)-1H-benzimidazole | Dexrabeprazole | E 3810 | E3810 | Pariet | Rabeprazole Sodium | Sodium, Rabeprazole | 1H-Benzimidazole, 2-(((4-(3-methoxypropoxy)-3-methyl-2-pyridinyl)methyl)sulfinyl)-, Sodium Salt | Aciphex | LY-307640 | LY 307640 | LY307640
Chemical Information
Molecular Formula C18H21N3O3S
CAS Registry Number 117976-89-3
SMILES CC1=C(C=CN=C1CS(=O)C2=NC3=CC=CC=C3N2)OCCCOC
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Gastric polyps07.20.01.003; 16.05.03.0010.006563%Not Available
Gastritis07.08.02.0010.001790%
Gastritis erosive07.04.03.0030.002386%Not Available
Gastrooesophageal reflux disease07.02.02.0030.004176%
Gastroenteritis11.01.07.004; 07.19.03.001--Not Available
Gastrointestinal carcinoma16.13.04.001; 07.21.03.001--Not Available
Gastrointestinal haemorrhage24.07.02.009; 07.12.02.001--Not Available
Gastrointestinal pain07.01.05.005--
Gingivitis11.01.04.013; 07.09.03.003--
Glaucoma06.03.01.002--
Glossitis07.14.01.001--Not Available
Gout14.09.01.001; 15.01.06.001--Not Available
Gynaecomastia21.05.04.003; 05.05.02.0030.001193%
Haematuria24.07.01.047; 20.02.01.006--
Haemoglobin decreased13.01.05.0030.001193%Not Available
Haemolytic anaemia01.06.03.002--Not Available
Hangover08.01.09.018--Not Available
Headache17.14.01.001--
Hepatic cirrhosis09.01.04.001--Not Available
Hepatic encephalopathy17.13.01.003; 09.01.03.006--Not Available
Hepatic function abnormal09.01.02.0010.001193%Not Available
Hepatic steatosis14.08.04.005; 09.01.07.003--Not Available
Hepatitis09.01.07.004--Not Available
Hernia08.01.04.001--Not Available
Herpes simplex11.05.02.001; 23.09.03.001--Not Available
Herpes virus infection11.05.02.008--Not Available
Herpes zoster23.09.03.002; 11.05.02.003--
Hiccups22.02.04.002; 07.01.06.009--
Hyperammonaemia14.10.01.001; 09.01.02.002--Not Available
Hypercholesterolaemia14.08.01.001--Not Available
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