Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Quinine sulfate
Drug ID BADD_D01897
Description An alkaloid derived from the bark of the cinchona tree. It is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633. Quinine is also a mild antipyretic and analgesic and has been used in common cold preparations for that purpose. It was used commonly and as a bitter and flavoring agent, and is still useful for the treatment of babesiosis. Quinine is also useful in some muscular disorders, especially nocturnal leg cramps and myotonia congenita, because of its direct effects on muscle membrane and sodium channels. The mechanisms of its antimalarial effects are not well understood.
Indications and Usage For the treatment of malaria and leg cramps
Marketing Status Prescription
ATC Code P01BC01
DrugBank ID DB00468
KEGG ID D02262
MeSH ID D011803
PubChem ID 16211610
TTD Drug ID D03DDR
NDC Product Code 68428-310; 72282-0004; 68084-947; 49452-6210; 12065-1704; 0093-3002; 0220-1306; 67729-001; 0220-1311; 68180-560; 50742-238; 0220-1307; 0220-1325; 49708-153; 62106-5706; 53489-700; 0220-1310; 0220-1314
Synonyms Quinine | Quinimax | Quinine Bisulfate | Bisulfate, Quinine | Quinine Hydrochloride | Hydrochloride, Quinine | Myoquin | Quinamm | Quinbisan | Legatrim | Quinine Lafran | Quinine Sulfate | Sulfate, Quinine | Quinine Sulphate | Sulphate, Quinine | Quinine-Odan | Quinoctal | Surquina | Biquinate | Strema | Quindan | Quinbisul | Quinson | Quinsul
Chemical Information
Molecular Formula C40H54N4O10S
CAS Registry Number 804-63-7
SMILES COC1=CC2=C(C=CN=C2C=C1)C(C3CC4CCN3CC4C=C)O.COC1=CC2=C(C=CN=C2C=C1)C(C3CC4CCN3CC4 C=C)O.O.O.OS(=O)(=O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Pancytopenia01.03.03.003--Not Available
Petechiae01.01.03.002; 24.07.06.004; 23.06.01.003--Not Available
Photophobia17.17.02.006; 06.01.01.004--
Photosensitivity reaction23.03.09.003--
Plasmodium falciparum infection11.06.04.003; 01.03.02.012--Not Available
Pruritus23.03.12.001--
Pulmonary oedema22.01.03.003; 02.05.02.003--
Pyrexia08.05.02.003--
Rash23.03.13.001--Not Available
Rash papular23.03.13.017--Not Available
Rash scarlatiniform23.03.13.006--Not Available
Renal failure20.01.03.005--Not Available
Restlessness17.02.05.021; 19.11.02.002--
Seizure17.12.03.001--
Stevens-Johnson syndrome23.03.01.007; 11.07.01.005; 12.03.01.014; 10.01.03.020--
Sudden visual loss17.17.01.014; 06.02.02.006--Not Available
Supraventricular extrasystoles02.03.03.011--Not Available
Syncope24.06.02.012; 17.02.04.008; 02.01.02.008--
Tachycardia02.03.02.007--Not Available
Thrombocytopenia01.08.01.002--Not Available
Thrombotic thrombocytopenic purpura24.07.06.014; 23.06.01.011; 01.08.01.005--
Tinnitus17.04.07.004; 04.04.01.002--
Torsade de pointes02.03.04.005--Not Available
Toxic epidermal necrolysis23.03.01.008; 12.03.01.015; 11.07.01.006; 10.01.01.006--
Tremor17.01.06.002--
Urticaria23.04.02.001; 10.01.06.001--
Vasodilatation24.03.02.003; 23.06.05.006--Not Available
Ventricular extrasystoles02.03.04.007--Not Available
Ventricular fibrillation02.03.04.008--
Ventricular tachycardia02.03.04.010--
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