Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Quinine
Drug ID BADD_D01895
Description An alkaloid derived from the bark of the cinchona tree. It is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633. Quinine is also a mild antipyretic and analgesic and has been used in common cold preparations for that purpose. It was used commonly and as a bitter and flavoring agent, and is still useful for the treatment of babesiosis. Quinine is also useful in some muscular disorders, especially nocturnal leg cramps and myotonia congenita, because of its direct effects on muscle membrane and sodium channels. The mechanisms of its antimalarial effects are not well understood.
Indications and Usage For the treatment of malaria and leg cramps
Marketing Status Prescription
ATC Code P01BC01
DrugBank ID DB00468
KEGG ID D08460
MeSH ID D011803
PubChem ID 3034034
TTD Drug ID D03DDR
NDC Product Code 65162-811
Synonyms Quinine | Quinimax | Quinine Bisulfate | Bisulfate, Quinine | Quinine Hydrochloride | Hydrochloride, Quinine | Myoquin | Quinamm | Quinbisan | Legatrim | Quinine Lafran | Quinine Sulfate | Sulfate, Quinine | Quinine Sulphate | Sulphate, Quinine | Quinine-Odan | Quinoctal | Surquina | Biquinate | Strema | Quindan | Quinbisul | Quinson | Quinsul
Chemical Information
Molecular Formula C20H24N2O2
CAS Registry Number 72402-53-0
SMILES COC1=CC2=C(C=CN=C2C=C1)C(C3CC4CCN3CC4C=C)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Flushing23.06.05.003; 24.03.01.002; 08.01.03.025--
Gastrointestinal disorder07.11.01.001--Not Available
Gastrointestinal pain07.01.05.005--
Granulocytosis01.02.01.008--Not Available
Granulomatous liver disease09.01.07.001--Not Available
Haemoglobin13.01.05.018--Not Available
Haemoglobinuria20.02.01.017; 01.06.04.005--
Haemolysis01.06.04.002--
Haemolytic anaemia01.06.03.002--Not Available
Haemolytic uraemic syndrome20.01.03.011; 01.06.02.001--
Headache17.14.01.001--
Hepatitis09.01.07.004--Not Available
Hepatotoxicity12.03.01.008; 09.01.07.009--Not Available
Hyperhidrosis08.01.03.028; 23.02.03.004--
Hypersensitivity10.01.03.003--
Hypertension24.08.02.0010.015136%
Hypoglycaemia14.06.03.001; 05.06.03.001--
Hypoprothrombinaemia01.01.01.001--Not Available
Hypotension24.06.03.002--
Immune system disorder10.02.01.001--Not Available
Jaundice01.06.04.004; 23.03.03.030; 09.01.01.004--Not Available
Leukopenia01.02.02.001--Not Available
Lichen planus23.03.08.001--Not Available
Liver function test abnormal13.03.01.013--Not Available
Loss of consciousness17.02.04.004--Not Available
Microangiopathic haemolytic anaemia24.03.02.019; 01.06.02.0020.028591%Not Available
Muscular weakness17.05.03.005; 15.05.06.001--
Myalgia15.05.02.001--
Myasthenia gravis10.04.05.001; 17.05.04.001; 15.05.08.001--
Mydriasis17.02.11.003; 06.05.03.004--Not Available
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